BRD7

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.^[5][6][7]

BRD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I7K
Identifiers
Aliases	BRD7, BP75, CELTIX1, NAG4, bromodomain containing 7, SMARCI1
External IDs	OMIM: 618489; MGI: 1349766; HomoloGene: 8085; GeneCards: BRD7; OMA:BRD7 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q12.1 Start 50,313,487 bp[1] End 50,368,988 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 88,331,039 bp[2] End 88,362,194 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone ganglionic eminence islet of Langerhans gonad Achilles tendon C1 segment right testis testicle popliteal artery Top expressed in genital tubercle tail of embryo ventricular zone zygote cardiac muscle tissue of left ventricle interventricular septum muscle of thigh secondary oocyte lens condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity histone binding p53 binding transcription factor binding protein binding transcription corepressor activity lysine-acetylated histone binding Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated negative regulation of G1/S transition of mitotic cell cycle cell cycle negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated Wnt signaling pathway transcription, DNA-templated negative regulation of cell population proliferation positive regulation of histone acetylation regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29117 26992 Ensembl ENSG00000166164 ENSMUSG00000031660 UniProt Q9NPI1 O88665 RefSeq (mRNA) NM_001173984 NM_013263 NM_012047 RefSeq (protein) NP_001167455 NP_037395 NP_036177 NP_001363942 NP_001363943 NP_001363944 NP_001363945 NP_001363946 Location (UCSC) Chr 16: 50.31 – 50.37 Mb Chr 8: 88.33 – 88.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

BRD7 has been shown to interact with IRF2^[8] and HNRPUL1.^[9]

Azoospermia

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.^[10] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.^[10]