HOMER2

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.^[5][6][7]

HOMER2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I7A
Identifiers
Aliases	HOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDs	OMIM: 604799; MGI: 1347354; HomoloGene: 3560; GeneCards: HOMER2; OMA:HOMER2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.2 Start 82,836,946 bp[1] End 82,986,153 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 81,250,229 bp[2] End 81,357,275 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas olfactory zone of nasal mucosa muscle of thigh minor salivary glands gastrocnemius muscle islet of Langerhans Skeletal muscle tissue of rectus abdominis skin of leg parotid gland skin of abdomen Top expressed in lacrimal gland parotid gland transitional epithelium of urinary bladder lateral septal nucleus substantia nigra Region I of hippocampus proper crypt of lieberkuhn of small intestine epithelium of stomach olfactory epithelium trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity protein domain specific binding synaptic receptor adaptor activity actin binding G protein-coupled glutamate receptor binding glutamate receptor binding protein heterodimerization activity Cellular component cytoplasm soma postsynaptic membrane dendrite synapse postsynaptic density membrane apical part of cell stereocilium tip cell projection stereocilium plasma membrane cell junction cytosol glutamatergic synapse neuron projection Biological process G protein-coupled glutamate receptor signaling pathway chemical homeostasis within a tissue behavioral response to cocaine regulation of G protein-coupled receptor signaling pathway hearing calcium-mediated signaling using intracellular calcium source negative regulation of interleukin-2 production negative regulation of calcineurin-NFAT signaling cascade regulation of store-operated calcium entry positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9455 26557 Ensembl ENSG00000103942 ENSMUSG00000025813 UniProt Q9NSB8 Q9QWW1 RefSeq (mRNA) NM_004839 NM_199330 NM_199331 NM_199332 NM_001164086 NM_001164087 NM_011983 NM_177029 RefSeq (protein) NP_004830 NP_955362 NP_001157558 NP_001157559 NP_036113 Location (UCSC) Chr 15: 82.84 – 82.99 Mb Chr 7: 81.25 – 81.36 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.^[7]

Interactions

HOMER2 has been shown to interact with RYR1.^[8]

See also

• HOMER1
• HOMER3