HOMER3

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.^[5][6][7]

HOMER3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P8V, 3CVF
Identifiers
Aliases	HOMER3, HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3
External IDs	OMIM: 604800; MGI: 1347359; HomoloGene: 37972; GeneCards: HOMER3; OMA:HOMER3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,929,201 bp[1] End 18,941,261 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,282,827 bp[2] End 70,294,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis right hemisphere of cerebellum C1 segment spleen muscle of thigh gastrocnemius muscle inferior ganglion of vagus nerve stromal cell of endometrium ganglionic eminence right lobe of thyroid gland Top expressed in cerebellar cortex lobe of cerebellum ventricular zone yolk sac cerebellar vermis dentate gyrus of hippocampal formation granule cell neural layer of retina lip ganglionic eminence embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding protein domain specific binding G protein-coupled glutamate receptor binding identical protein binding Cellular component basal part of cell cell junction postsynaptic membrane synapse postsynaptic density membrane cytoplasm cytosol plasma membrane cellular component glutamatergic synapse dendrite neuron projection Biological process G protein-coupled glutamate receptor signaling pathway protein targeting negative regulation of interleukin-2 production negative regulation of calcineurin-NFAT signaling cascade regulation of postsynaptic neurotransmitter receptor activity regulation of store-operated calcium entry Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9454 26558 Ensembl ENSG00000051128 ENSMUSG00000003573 UniProt Q9NSC5 Q99JP6 RefSeq (mRNA) NM_001145721 NM_001145722 NM_001145724 NM_004838 NM_001146153 NM_011984 RefSeq (protein) NP_001139193 NP_001139194 NP_001139196 NP_004829 NP_001139194.1 NP_001139196.1 NP_001139625 NP_036114 Location (UCSC) Chr 19: 18.93 – 18.94 Mb Chr 8: 70.28 – 70.29 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.^[7]

Interactions

HOMER3 has been shown to interact with TRPC1^[8] and RYR1.^[9]

See also

• HOMER1
• HOMER2