HOT-x

HOT-x, also known as 4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines or hydroxylated 2C-T derivatives, are a group of psychedelic drugs of the phenethylamine and 2C families.^[1][2] They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring.^[1][2] The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs.^[1][2]

HOT-2, a psychedelic drug of the HOT-x group.^[1][2]

The HOT-x drugs were synthesized and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[1][2]

Use and effects

Oral doses and durations of HOT-x drugs

Compound	Chemical name	Dose	Duration
HOT-2 (N-hydroxy-2C-T-2)	N-Hydroxy-4-ethylthio-2,5-dimethoxyphenethylamine	10–18 mg	6–10 hours
HOT-7 (N-hydroxy-2C-T-7)	N-Hydroxy-4-propylthio-2,5-dimethoxyphenethylamine	15–25 mg	6–8 hours
HOT-17 (N-hydroxy-2C-T-17)	N-Hydroxy-4-sec-butylthio-2,5-dimethoxyphenethylamine	70–120 mg	12–18 hours
Refs: [2][3][4]

All three of the HOT-x drugs produce psychedelic effects according to Shulgin.^[1][2] The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act as prodrugs to these compounds.^[2]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

See also

• 2C (psychedelics)
• Substituted methoxyphenethylamine
• MDOH (MDH; N-OH-MDA)
• MDHMA (FLEA; N-OH-MDMA)
• 2C-B-OH (N-hydroxy-2C-B)
• N-Hydroxy-DOM
• N-Hydroxy-AMT