HOT-x

HOT-x, also known as 2,5-dimethoxy-4-(β-alkylthio)-N-hydroxyphenethylamines, are a group of psychedelic drugs of the phenethylamine and 2C families.^[1][2] They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring.^[1][2] The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs.^[1][2] They were synthesized and tested by Alexander Shulgin and reported in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[1][2]

HOT-2, a psychedelic drug of the HOT-x group.^[1][2]

List of HOT-x drugs

The HOT-x drugs include the following:^[1][2]

• HOT-2 (2,5-dimethoxy-4-(β-ethylthio)-N-hydroxyphenethylamine) – the HOT-x analogue of 2C-T-2^[1][2]
• HOT-7 (2,5-dimethoxy-4-(β-propylthio)-N-hydroxyphenethylamine) – the HOT-x analogue of 2C-T-7^[1][2]
• HOT-17 (2,5-dimethoxy-4-(β-isobutylthio)-N-hydroxyphenethylamine) – the HOT-x analogue of 2C-T-17^[1][2]

All three of the HOT-x drugs produce psychedelic effects according to Shulgin.^[1][2] HOT-x drugs are said to be very similar to their 2C-T counterparts and might act as prodrugs to these compounds.^[2]

See also

• MDOH (MDH; N-OH-MDA)
• MDHMA (FLEA; N-OH-MDMA)