HOT-2

HOT-2 (2,5-dimethoxy-4-(β-ethylthio)-N-hydroxyphenethylamine) is a psychedelic phenethylamine of the 2C and HOT-x families. It was presumably first synthesized by Alexander Shulgin and reported in his book PiHKAL.^[1]

HOT-2

Names
Preferred IUPAC name 2-[4-(Ethylsulfanyl)-2,5-dimethoxyphenyl]-N-hydroxyethan-1-amine
Other names 2-[4-(Ethylthio)-2,5-dimethoxyphenyl]ethanaminol
Identifiers
CAS Number	207740-38-3 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL127595 Y
ChemSpider	21106320 Y
PubChem CID	44350142
UNII	A9AD8C69LQ Y
CompTox Dashboard (EPA)	DTXSID00658383
InChI InChI=1S/C12H19NO3S/c1-4-17-12-8-10(15-2)9(5-6-13-14)7-11(12)16-3/h7-8,13-14H,4-6H2,1-3H3 Y Key: XGFJCRNRWOXGQM-UHFFFAOYSA-N Y InChI=1/C12H19NO3S/c1-4-17-12-8-10(15-2)9(5-6-13-14)7-11(12)16-3/h7-8,13-14H,4-6H2,1-3H3 Key: XGFJCRNRWOXGQM-UHFFFAOYAO
SMILES CCSc1cc(OC)c(cc1OC)CCNO
Properties
Chemical formula	C12H19NO3S
Molar mass	257.35 g·mol−1
Melting point	122 °C (252 °F; 395 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Chemistry

HOT-2's full chemical name is 2-[4-(2-ethylthio)-2,5-dimethoxyphenyl–N–hydroxyethanamine. It has structural properties similar to 2C-T-2 and to other drugs in the HOT- series, with the most closely related compounds being HOT-7 and HOT-17.

General information

The dosage range of HOT-2 is typically 10-18 mg and its duration is approximately 6–10 hours according to Shulgin.^[1] HOT-2 produces visuals and moving, flowing lights. It also causes euphoria and increases blood pressure.

Legality

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.^[2]

See also

• Phenethylamine