HOT-7

HOT-7, also known as 4-propylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-7, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families.^[1] It is the N-hydroxy derivative of 2C-T-7.^[1] The drug is taken orally.^[1]

HOT-7

Clinical data
Other names	4-Propylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-propylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-7; N-OH-2C-T-7
Routes of administration	Oral[1]
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None
Pharmacokinetic data
Metabolites	Possibly 2C-T-7[1][2]
Onset of action	Unknown[1]
Duration of action	6–8 hours[1]
Identifiers
IUPAC name 2-[2,5-Dimethoxy-4-(propylsulfanyl)phenyl]-N-hydroxyethan-1-amine
CAS Number	207740-39-4 Y
PubChem CID	44350017
ChemSpider	21106321 Y
UNII	J43NT74JXX
ChEMBL	ChEMBL127582 Y
CompTox Dashboard (EPA)	DTXSID90658372
Chemical and physical data
Formula	C13H21NO3S
Molar mass	271.38 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc1cc(SCCC)c(cc1CCNO)OC
InChI InChI=1S/C13H21NO3S/c1-4-7-18-13-9-11(16-2)10(5-6-14-15)8-12(13)17-3/h8-9,14-15H,4-7H2,1-3H3 Y Key:ASTNLROMDNGJLS-UHFFFAOYSA-N Y
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Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-7's dose range as 15 to 20 mg orally and its duration as 6 to 8 hours.^[1] The drug's onset and peak of effects were not described.^[1] HOT-7's properties are similar to those of 2C-T-7, which has a dose of 10 to 30 mg orally and a duration of 8 to 15 hours, although HOT-7 may have a somewhat shorter duration.^[1][2] HOT-7 may act as a prodrug of 2C-T-7.^[2]

The effects of HOT-7 have been reported to include being "quite psychedelic", very rich in closed-eye imagery, not as much in terms of open-eye visuals, very good for interpretive and conceptual thinking, emotional changes, feeling "smoothly stoned", lightheadedness, alcohol-like tipsiness and wooziness, social avoidance, and gastrointestinal disturbances.^[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Synthesis

The chemical synthesis of HOT-7 has been described.^[1]

Analogues

Analogues of HOT-7 include 2C-T-7, HOT-2 (N-hydroxy-2C-T-2), and HOT-17 (N-hydroxy-2C-T-17), among others.^[1]

History

HOT-7 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[1]

Society and culture

Legal status

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.^[3]

See also

• HOT-x (psychedelics)