HOT-17

HOT-17, also known as 4-sec-butylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-17, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families.^[1][3] It is the N-hydroxy derivative of 2C-T-17.^[1][3] The drug is taken orally.^[1]

HOT-17

Clinical data
Other names	4-sec-Butylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-sec-butylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-17; N-OH-2C-T-17
Routes of administration	Oral[1]
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None
Pharmacokinetic data
Metabolites	Possibly 2C-T-17[1][2]
Onset of action	0.5–1.5 hours[1] Peak: 3 hours[1]
Duration of action	12–18 hours[1]
Identifiers
IUPAC name 2-{4-[(butan-2-yl)sulfanyl]-2,5-dimethoxyphenyl}-N-hydroxyethan-1-amine
CAS Number	207740-40-7 Y
PubChem CID	44350007
ChemSpider	21106319 Y
UNII	A9AD8C69LQ
ChEMBL	ChEMBL127509 Y
CompTox Dashboard (EPA)	DTXSID70658370
Chemical and physical data
Formula	C14H23NO3S
Molar mass	285.40 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(CC)Sc1cc(OC)c(cc1OC)CCNO
InChI InChI=1S/C14H23NO3S/c1-5-10(2)19-14-9-12(17-3)11(6-7-15-16)8-13(14)18-4/h8-10,15-16H,5-7H2,1-4H3 Y Key:BUKIXGXYEUJJHQ-UHFFFAOYSA-N Y
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Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-17's dose range as 70 to 120 mg orally and its duration as 12 to 18 hours.^[1] The drug's onset is 30 minutes to 1.5 hours and peak effects occur after 3 hours.^[1] HOT-17's properties are very similar to those of 2C-T-17, which has a dose of 60 to 100 mg orally, a duration of 10 to 15 hours, and an onset of 1 hour with a time to peak of 3 hours.^[1][2] HOT-17 may act as a prodrug of 2C-T-17.^[2]

The effects of HOT-17 have been reported to include "something going on upstairs", no sensory distortion, mild time distortion, feeling light and slightly floaty, walking feeling pleasant due to the lightness, and no body load, among others.^[1] It was described as producing "plus-two" and "plus-three" experiences on the Shulgin Rating Scale.^[1] The compound is said to have an "unbelievably grim taste—not bitter, but simply evil".^[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Synthesis

The chemical synthesis of HOT-17 has been described.^[1]

Analogues

Analogues of HOT-17 include 2C-T-17, HOT-2 (N-hydroxy-2C-T-2), and HOT-7 (N-hydroxy-2C-T-7), among others.^[1][3]

History

HOT-17 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[1][3]

See also

• HOT-x (psychedelics)