HOXB4

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.^[5][6][7]

HOXB4
Identifiers
Aliases	HOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4
External IDs	OMIM: 142965; MGI: 96185; HomoloGene: 32095; GeneCards: HOXB4; OMA:HOXB4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,575,507 bp[1] End 48,578,350 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.83 cM Start 96,209,093 bp[2] End 96,212,464 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube muscle layer of sigmoid colon gastric mucosa endometrium Descending thoracic aorta left uterine tube human kidney right lung fundus right adrenal gland Top expressed in tail of embryo thoracic vertebral column migratory enteric neural crest cell medullary collecting duct ascending aorta granulocyte female urethra inner root sheath primitive streak renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus centrosome Biological process embryonic skeletal system morphogenesis multicellular organism development definitive hemopoiesis somatic stem cell division skeletal system morphogenesis cell population proliferation positive regulation of stem cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II spleen development hematopoietic stem cell differentiation morphogenesis of an epithelial sheet transcription, DNA-templated anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II bone marrow development hemopoiesis skeletal system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3214 15412 Ensembl ENSG00000182742 ENSMUSG00000038692 UniProt P17483 P10284 RefSeq (mRNA) NM_024015 NM_010459 RefSeq (protein) NP_076920 NP_034589 Location (UCSC) Chr 17: 48.58 – 48.58 Mb Chr 11: 96.21 – 96.21 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.^[7]

See also

• Homeobox