HSPBP1

Hsp70-binding protein 1 is a protein that in humans is encoded by the HSPBP1 gene.^[5][6][7]

HSPBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XQR, 1XQS
Identifiers
Aliases	HSPBP1, FES1, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA (Hsp70) binding protein 1
External IDs	OMIM: 612939; MGI: 1913495; HomoloGene: 40827; GeneCards: HSPBP1; OMA:HSPBP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,262,223 bp[1] End 55,280,381 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,663,520 bp[2] End 4,688,067 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens right uterine tube caudate nucleus putamen right frontal lobe apex of heart cingulate gyrus anterior cingulate cortex amygdala mucosa of transverse colon Top expressed in spermatid primary visual cortex perirhinal cortex right kidney entorhinal cortex superior frontal gyrus morula embryo dentate gyrus of hippocampal formation granule cell CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity protein binding adenyl-nucleotide exchange factor activity ubiquitin protein ligase binding Cellular component cytoplasm endoplasmic reticulum Biological process positive regulation of protein ubiquitination protein folding positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of catalytic activity regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23640 66245 Ensembl ENSG00000133265 ENSMUSG00000063802 UniProt Q9NZL4 Q99P31 RefSeq (mRNA) NM_001130106 NM_001297600 NM_012267 NM_024172 NM_001360629 RefSeq (protein) NP_001123578 NP_001284529 NP_036399 NP_077134 NP_001347558 Location (UCSC) Chr 19: 55.26 – 55.28 Mb Chr 7: 4.66 – 4.69 Mb PubMed search [3] [4]
Wikidata
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Interactions

HSPBP1 has been shown to interact with HSPA8^[8][9] and HSPA4.^[10]