Hypidone

Hypidone
Clinical data
Other names	YL-0919; YL0919
Identifiers
	IUPAC name 1-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]pyridin-2-one;
CAS Number	1339339-18-2 ; 1339058-04-6 (HCl);
PubChem CID	54673543;
ChemSpider	68055492;
Chemical and physical data
Formula	C18H22N2O2
Molar mass	298.386 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCC1(CN2C=CC=CC2=O)O)CC3=CC=CC=C3;
	InChI InChI=1S/C18H22N2O2/c21-17-8-4-5-11-20(17)15-18(22)9-12-19(13-10-18)14-16-6-2-1-3-7-16/h1-8,11,22H,9-10,12-15H2; Key:BGMVOROUOUVVRV-UHFFFAOYSA-N;

Hypidone (developmental code name YL-0919) is an investigational serotonergic antidepressant which is under development for the treatment of major depressive disorder.^[1]^[2]^[3]^[4]^[5] It acts as a serotonin reuptake inhibitor, 5-HT_1A receptor partial agonist, and 5-HT₆ receptor full agonist.^[1]^[5] It is used as the hydrochloride salt.^[2]^[5] As of January 2021, hypidone is in phase 2 clinical trials for major depressive disorder.^[1]

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See also