IRS4

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.^[5][6][7]

IRS4
Identifiers
Aliases	IRS4, IRS-4, PY160, insulin receptor substrate 4, CHNG9
External IDs	OMIM: 300904; MGI: 1338009; HomoloGene: 136777; GeneCards: IRS4; OMA:IRS4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.3 Start 108,719,946 bp[1] End 108,736,563 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F2|X 62.43 cM Start 140,493,994 bp[2] End 140,508,259 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary ovary left ovary right ovary gastric mucosa hypothalamus body of uterus right lobe of thyroid gland cervix Top expressed in median eminence arcuate nucleus ventromedial nucleus dorsomedial hypothalamic nucleus substantia nigra gastrula mammillary body lateral hypothalamus nucleus of stria terminalis paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol 3-kinase binding protein binding signal transducer activity insulin receptor binding Cellular component cytosol membrane plasma membrane Biological process insulin receptor signaling pathway regulation of lipid metabolic process signal transduction positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8471 16370 Ensembl ENSG00000133124 ENSMUSG00000054667 UniProt O14654 Q9Z0Y7 RefSeq (mRNA) NM_003604 NM_001379150 NM_010572 RefSeq (protein) NP_003595 NP_001366079 NP_034702 Location (UCSC) Chr X: 108.72 – 108.74 Mb Chr X: 140.49 – 140.51 Mb PubMed search [3] [4]
Wikidata
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IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.^[7]

Interactions

IRS4 has been shown to interact with CRK^[8][9] and NISCH.^[10]