NISCH

Nischarin is a protein that in humans is encoded by the NISCH gene.^[5][6][7][8]

NISCH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P0C
Identifiers
Aliases	NISCH, I-1, IR1, IRAS, hIRAS, nischarin
External IDs	OMIM: 615507; MGI: 1928323; HomoloGene: 130564; GeneCards: NISCH; OMA:NISCH - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 52,455,118 bp[1] End 52,493,068 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 30,892,887 bp[2] End 30,938,903 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus right hemisphere of cerebellum pituitary gland anterior pituitary Brodmann area 23 paraflocculus of cerebellum canal of the cervix tibial nerve entorhinal cortex left ovary Top expressed in internal carotid artery external carotid artery CA3 field saccule Rostral migratory stream entorhinal cortex perirhinal cortex condyle choroid plexus of fourth ventricle fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding protein binding phosphatidylinositol binding identical protein binding structural constituent of cytoskeleton protein kinase binding Cellular component cytoplasm recycling endosome cytosol endosome plasma membrane early endosome membrane Biological process regulation of blood pressure Rac protein signal transduction negative regulation of cell migration regulation of synaptic transmission, GABAergic actin cytoskeleton organization norepinephrine secretion glucose metabolic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11188 64652 Ensembl ENSG00000010322 ENSMUSG00000021910 UniProt Q9Y2I1 Q80TM9 RefSeq (mRNA) NM_001276293 NM_001276294 NM_007184 NM_022656 NM_001347583 RefSeq (protein) NP_001263222 NP_001263223 NP_009115 NP_001334512 NP_073147 Location (UCSC) Chr 3: 52.46 – 52.49 Mb Chr 14: 30.89 – 30.94 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane as well as early and recycling endosome membranes. It is a scaffold protein related to Sorting nexins and it regulates protein cargo traffic. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.^[7][8]

Clinical significance

Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.^[7]

Interactions

NISCH has been shown to interact with IRS4,^[5] Integrin alpha 5,^[9] and small GTPases Rac1, Rab4a, Rab9a, Rab14 and Rab38 in GTP-bound form.^[10] NISCH also interacts with phospholipid PI(3)P via its PX domain.^[11]

See also

• Imidazoline receptor