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Integrin alpha V
Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia
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Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[5]
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Function
ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[6]
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Alpha V class integrins
In mammals the integrins that include alpha-V are :
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Clinical significance
Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer,[10] and prostate cancer.[11]
As a drug target
The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.[12]
See also
References
Further reading
External links
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