Integrin beta 3

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.^[5] CD61 is a cluster of differentiation found on thrombocytes.^[6]

ITGB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
Identifiers
Aliases	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
External IDs	OMIM: 173470; MGI: 96612; HomoloGene: 55444; GeneCards: ITGB3; OMA:ITGB3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,253,827 bp[1] End 47,313,743 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.84 cM Start 104,498,826 bp[2] End 104,561,302 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte thoracic aorta ascending aorta Descending thoracic aorta right lobe of thyroid gland left lobe of thyroid gland tendon of biceps brachii popliteal artery tibial arteries right coronary artery Top expressed in ascending aorta aortic valve decidua blood endothelial cell of lymphatic vessel granulocyte superior surface of tongue femur body of femur zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor receptor 2 binding fibronectin binding virus receptor activity extracellular matrix binding protein disulfide isomerase activity protease binding platelet-derived growth factor receptor binding protein binding identical protein binding enzyme binding cell adhesion molecule binding neuregulin binding coreceptor activity fibroblast growth factor binding insulin-like growth factor I binding C-X3-C chemokine binding integrin binding fibrinogen binding Cellular component integral component of membrane cell projection alphav-beta3 integrin-vitronectin complex membrane focal adhesion melanosome receptor complex plasma membrane integral component of plasma membrane ruffle membrane cell surface cell junction integrin complex platelet alpha granule membrane integrin alphav-beta3 complex extracellular exosome lamellipodium membrane nucleus microvillus membrane filopodium membrane alphav-beta3 integrin-IGF-1-IGF1R complex alphav-beta3 integrin-PKCalpha complex alphav-beta3 integrin-HMGB1 complex glutamatergic synapse synapse Biological process negative regulation of lipoprotein metabolic process apolipoprotein A-I-mediated signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein phosphorylation regulation of cell migration negative chemotaxis positive regulation of endothelial cell proliferation tube development heterotypic cell-cell adhesion angiogenesis involved in wound healing wound healing platelet degranulation blood coagulation extracellular matrix organization smooth muscle cell migration positive regulation of endothelial cell migration cell growth cell-substrate adhesion vascular endothelial growth factor receptor signaling pathway cell adhesion positive regulation of peptidyl-tyrosine phosphorylation mesodermal cell differentiation cell-substrate junction assembly integrin-mediated signaling pathway negative regulation of lipid storage substrate adhesion-dependent cell spreading negative regulation of lipid transport cell-matrix adhesion viral process regulation of bone resorption platelet aggregation cell migration negative regulation of macrophage derived foam cell differentiation activation of protein kinase activity leukocyte migration cell adhesion mediated by integrin platelet activation apoptotic cell clearance regulation of postsynaptic neurotransmitter receptor internalization regulation of protein localization regulation of serotonin uptake Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3690 16416 Ensembl ENSG00000259207 ENSMUSG00000020689 UniProt P05106 O54890 RefSeq (mRNA) NM_000212 NM_016780 RefSeq (protein) NP_000203 NP_058060 Location (UCSC) Chr 17: 47.25 – 47.31 Mb Chr 11: 104.5 – 104.56 Mb PubMed search [3] [4]
Wikidata
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Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.^[7]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.^[8]

Interactions

CD61 has been shown to interact with PTK2,^[9][10] ITGB3BP,^[11][12] TLN1^[13][14] and CIB1.^[15]

See also

• Glycoprotein IIb/IIIa