ITGB3BP

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.^[5][6][7]

ITGB3BP
Identifiers
Aliases	ITGB3BP, CENP-R, CENPR, HSU37139, NRIF3, TAP20, integrin subunit beta 3 binding protein
External IDs	OMIM: 605494; MGI: 1914983; HomoloGene: 8617; GeneCards: ITGB3BP; OMA:ITGB3BP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 63,440,770 bp[1] End 63,593,721 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 99,653,639 bp[2] End 99,787,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte Achilles tendon secondary oocyte testicle right uterine tube ventricular zone sperm ganglionic eminence gonad right testis Top expressed in testicle spermatocyte ventricular zone spermatid quadriceps femoris muscle epiblast embryo proximal tubule right kidney neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein C-terminus binding protein binding Cellular component cytoplasm cytosol membrane nucleoplasm chromosome chromosome, centromeric region nucleus kinetochore Biological process regulation of transcription, DNA-templated CENP-A containing chromatin assembly transcription, DNA-templated cell division cell adhesion positive regulation of apoptotic process cell cycle signal transduction apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23421 67733 Ensembl ENSG00000142856 ENSMUSG00000028549 UniProt Q13352 Q9CQ82 RefSeq (mRNA) NM_001206739 NM_014288 NM_001347145 NM_001347147 NM_001347148 NM_026348 NM_001362974 NM_001362975 NM_001362976 RefSeq (protein) NP_001193668 NP_001334074 NP_001334076 NP_001334077 NP_055103 NP_080624 NP_001349903 NP_001349904 NP_001349905 Location (UCSC) Chr 1: 63.44 – 63.59 Mb Chr 4: 99.65 – 99.79 Mb PubMed search [3] [4]
Wikidata
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Interactions

ITGB3BP has been shown to interact with:

• CD61,^[5][8]
• Cyclin A2,^[9]
• NFKB1,^[10]
• RXRA,^[6]
• RXRG,^[11] and
• THRA.^[6][11]