Integrin beta 7

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.^[5][6] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α₄β₇, or with ITGAE (CD103) to form α_Eβ₇.^[7]

ITGB7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BRQ, 3V4P, 3V4V
Identifiers
Aliases	ITGB7, integrin subunit beta 7
External IDs	OMIM: 147559; MGI: 96616; HomoloGene: 20247; GeneCards: ITGB7; OMA:ITGB7 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,191,323 bp[1] End 53,207,282 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.39 cM Start 102,124,430 bp[2] End 102,140,379 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node bone marrow cells blood spleen cecum appendix mononuclear cell monocyte trachea Top expressed in blood mesenteric lymph nodes granulocyte spleen thymus morula morula corneal stroma bone marrow subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity metal ion binding protein binding cell adhesion molecule binding integrin binding signaling receptor activity Cellular component integral component of membrane membrane receptor complex plasma membrane cell surface integrin complex extracellular exosome integrin alpha4-beta7 complex focal adhesion Biological process T cell migration heterotypic cell-cell adhesion cell-matrix adhesion involved in ameboidal cell migration extracellular matrix organization receptor clustering cell adhesion regulation of immune response leukocyte tethering or rolling integrin-mediated signaling pathway viral entry into host cell substrate adhesion-dependent cell spreading cell-matrix adhesion leukocyte migration cell migration cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3695 16421 Ensembl ENSG00000139626 ENSMUSG00000001281 UniProt P26010 P26011 RefSeq (mRNA) NM_000889 NM_013566 RefSeq (protein) NP_000880 NP_038594 Location (UCSC) Chr 12: 53.19 – 53.21 Mb Chr 15: 102.12 – 102.14 Mb PubMed search [3] [4]
Wikidata
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Structure

Like all integrin subunits, β₇ is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.^[8] Beginning with the apical end of the protein, farthest from the cell membrane, the β₇ is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.^[9]

Interactions

ITGB7 has been shown to interact with EED.^[10]