Interleukin-21 receptor

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.^[5]

IL21R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TGX, 4NZD
Identifiers
Aliases	IL21R, CD360, NILR, interleukin 21 receptor, IMD56
External IDs	OMIM: 605383; MGI: 1890475; HomoloGene: 11040; GeneCards: IL21R; OMA:IL21R - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 27,402,174 bp[1] End 27,452,042 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 125,202,601 bp[2] End 125,232,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood appendix epithelium of nasopharynx tonsil spleen bone marrow bone marrow cells superficial temporal artery Top expressed in thymus mesenteric lymph nodes spleen subcutaneous adipose tissue stroma of bone marrow granulocyte ascending aorta blood aortic valve mandible More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity interleukin-21 receptor activity transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process natural killer cell activation interleukin-21-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50615 60504 Ensembl ENSG00000103522 ENSMUSG00000030745 UniProt Q9HBE5 Q9JHX3 RefSeq (mRNA) NM_021798 NM_181078 NM_181079 NM_021887 RefSeq (protein) NP_068570 NP_851564 NP_851565 NP_068687 Location (UCSC) Chr 16: 27.4 – 27.45 Mb Chr 7: 125.2 – 125.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma chain (γc), a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.^[5]