Interleukin-6 receptor

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

IL6R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N26, 1P9M, 2ARW
Identifiers
Aliases	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, Interleukin-6 receptor, interleukin 6 receptor
External IDs	OMIM: 147880; MGI: 105304; HomoloGene: 474; GeneCards: IL6R; OMA:IL6R - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,405,193 bp[1] End 154,469,450 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.19 cM Start 89,771,366 bp[2] End 89,820,503 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte right lobe of liver gastrocnemius muscle granulocyte trabecular bone bone marrow cells synovial joint saphenous vein gastric mucosa Top expressed in granulocyte blood islet of Langerhans decidua muscle of thigh lip left lobe of liver tibiofemoral joint esophagus lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ciliary neurotrophic factor receptor activity protein homodimerization activity interleukin-6 receptor binding protein binding cytokine receptor activity enzyme binding ciliary neurotrophic factor binding interleukin-6 receptor activity interleukin-6 binding interleukin-12 receptor binding growth factor activity cytokine binding interleukin-12 alpha subunit binding interleukin-23 receptor binding Cellular component integral component of membrane membrane plasma membrane extracellular region basolateral plasma membrane apical plasma membrane interleukin-6 receptor complex ciliary neurotrophic factor receptor complex extracellular space cell surface external side of plasma membrane receptor complex interleukin-12 complex interleukin-23 complex Biological process positive regulation of activation of Janus kinase activity response to cytokine hepatic immune response extrinsic apoptotic signaling pathway monocyte chemotaxis ciliary neurotrophic factor-mediated signaling pathway positive regulation of leukocyte chemotaxis negative regulation of interleukin-8 production positive regulation of osteoblast differentiation defense response to Gram-negative bacterium acute-phase response positive regulation of NF-kappaB transcription factor activity positive regulation of cell population proliferation positive regulation of interleukin-6 production positive regulation of peptidyl-tyrosine phosphorylation positive regulation of chemokine production neutrophil mediated immunity negative regulation of collagen biosynthetic process endocrine pancreas development positive regulation of MAPK cascade positive regulation of smooth muscle cell proliferation defense response to Gram-positive bacterium positive regulation of tyrosine phosphorylation of STAT protein cytokine-mediated signaling pathway interleukin-6-mediated signaling pathway positive regulation of T-helper 1 type immune response regulation of signaling receptor activity positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of activated T cell proliferation positive regulation of lymphocyte proliferation positive regulation of NK T cell activation positive regulation of glomerular mesangial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3570 16194 Ensembl ENSG00000160712 ENSMUSG00000027947 UniProt P08887 P22272 RefSeq (mRNA) NM_000565 NM_001206866 NM_181359 NM_010559 NM_001310676 RefSeq (protein) NP_000556 NP_001193795 NP_852004 NP_001369698 NP_001369699 NP_001369700 NP_001369701 NP_001369702 NP_001369703 NP_001297605 NP_034689 Location (UCSC) Chr 1: 154.41 – 154.47 Mb Chr 3: 89.77 – 89.82 Mb PubMed search [3] [4]
Wikidata
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Function

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytes IL6R gene expression may be regulated by MITF.^[5]

Structure

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6] IL6R subunit is also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to interact with Interleukin 6^[7][8][9] and ciliary neurotrophic factor.^[8][10]

See also

• Cluster of differentiation
• Anti-IL-6
  • Tocilizumab, a monoclonal antibody against IL6R
  • Sarilumab, a monoclonal antibody against IL6R
  • LMT-28, a small molecule antagonist of IL6R