Interleukin-9 receptor

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.^[5]

IL9R
Identifiers
Aliases	IL9R, CD129, IL-9R, interleukin 9 receptor
External IDs	OMIM: 300007; MGI: 96564; HomoloGene: 37591; GeneCards: IL9R; OMA:IL9R - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 and Yq12 Start 155,997,696 bp[1] End 156,010,817 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 32,137,541 bp[2] End 32,150,279 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad lymph node granulocyte appendix spleen right uterine tube rectum urinary bladder blood mucosa of transverse colon Top expressed in spermatocyte embryo thymus neural layer of retina spermatid spleen lip adrenal gland muscle nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity interleukin-9 receptor activity protein binding Cellular component integral component of membrane integral component of plasma membrane membrane extracellular region extracellular space plasma membrane Biological process cell population proliferation signal transduction interleukin-9-mediated signaling pathway regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3581 16199 Ensembl ENSG00000124334 ENSMUSG00000020279 UniProt Q01113 Q01114 RefSeq (mRNA) NM_002186 NM_176786 NM_001134458 NM_008374 RefSeq (protein) NP_002177 NP_789743 NP_001127930 NP_032400 Location (UCSC) Chr X: 156 – 156.01 Mb Chr 11: 32.14 – 32.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[5]

Interactions

Interleukin-9 receptor has been shown to interact with YWHAZ.^[6]

See also

• Cluster of differentiation