JAM2

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.^[5][6][7] JAM2 has also been designated as CD322 (cluster of differentiation 322).

JAM2
Identifiers
Aliases	JAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM, junctional adhesion molecule 2, IBGC8
External IDs	OMIM: 606870; MGI: 1933820; HomoloGene: 10929; GeneCards: JAM2; OMA:JAM2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 25,639,258 bp[1] End 25,717,562 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 84,571,011 bp[2] End 84,622,816 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone tendon of biceps brachii vena cava internal globus pallidus ganglionic eminence pericardium gastric mucosa body of uterus epithelium of colon tibial nerve Top expressed in interventricular septum myocardium of ventricle cumulus cell right ventricle cardiac muscles neural layer of retina deep cerebellar nuclei iris epithelium of lens substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane membrane bicellular tight junction Biological process negative regulation of cell adhesion extracellular matrix organization leukocyte migration cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58494 67374 Ensembl ENSG00000154721 ENSMUSG00000053062 UniProt P57087 Q9JI59 RefSeq (mRNA) NM_001270407 NM_001270408 NM_021219 NM_023844 RefSeq (protein) NP_001257336 NP_001257337 NP_067042 NP_076333 Location (UCSC) Chr 21: 25.64 – 25.72 Mb Chr 16: 84.57 – 84.62 Mb PubMed search [3] [4]
Wikidata
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Function

Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.^[7]

It is purported to promote lymphocyte transendothelial migration.^[8] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.^[9]

Interactions

JAM2 has been shown to interact with PARD3.^[9]

It also interacts with the integrin dimer VLA-4 (also called α4β1).^[10]