KCNA2

Potassium voltage-gated channel subfamily A member 2 also known as K_v1.2 is a protein that in humans is encoded by the KCNA2 gene.^[5][6]

KCNA2
Identifiers
Aliases	KCNA2, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, EIEE32, potassium voltage-gated channel subfamily A member 2, DEE32
External IDs	OMIM: 176262; MGI: 96659; HomoloGene: 21034; GeneCards: KCNA2; OMA:KCNA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,519,837 bp[1] End 110,631,474 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.61 cM Start 107,008,462 bp[2] End 107,022,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus lateral nuclear group of thalamus postcentral gyrus primary visual cortex cerebellar vermis superior frontal gyrus Pons Brodmann area 46 endothelial cell Top expressed in lateral geniculate nucleus pontine nuclei lobe of cerebellum medial geniculate nucleus anterior horn of spinal cord medial vestibular nucleus medial dorsal nucleus deep cerebellar nuclei cerebellar vermis facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel activity voltage-gated ion channel activity ion channel activity protein binding voltage-gated potassium channel activity delayed rectifier potassium channel activity outward rectifier potassium channel activity kinesin binding Cellular component juxtaparanode region of axon axon terminus integral component of membrane perikaryon cell projection endoplasmic reticulum membrane membrane voltage-gated potassium channel complex plasma membrane synapse integral component of plasma membrane neuronal cell body membrane axon cell junction dendrite endoplasmic reticulum neuron projection lamellipodium membrane presynaptic membrane lamellipodium potassium channel complex paranodal junction calyx of Held integral component of presynaptic membrane Biological process regulation of dopamine secretion regulation of ion transmembrane transport ion transport optic nerve structural organization potassium ion transport transmembrane transport potassium ion transmembrane transport regulation of circadian sleep/wake cycle, non-REM sleep protein homooligomerization protein complex oligomerization sensory perception of pain neuronal action potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3737 16490 Ensembl ENSG00000177301 ENSMUSG00000040724 UniProt P16389 P63141 RefSeq (mRNA) NM_001204269 NM_004974 NM_008417 RefSeq (protein) NP_001191198 NP_004965 NP_032443 Location (UCSC) Chr 1: 110.52 – 110.63 Mb Chr 3: 107.01 – 107.02 Mb PubMed search [3] [4]
Wikidata
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Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.^[6]

Interactions

KCNA2 has been shown to interact with KCNA4,^[7] DLG4,^[8] PTPRA,^[9] KCNAB2,^[7][10] RHOA^[11] and Cortactin.^[12]

Clinical

Mutations in this gene have been associated with hereditary spastic paraplegia.^[13]

See also

• Voltage-gated potassium channel
• Pandinotoxin