KCNAB2

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.^[5][6]

KCNAB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZSX
Identifiers
Aliases	KCNAB2, AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2, potassium voltage-gated channel subfamily A regulatory beta subunit 2
External IDs	OMIM: 601142; MGI: 109239; HomoloGene: 56492; GeneCards: KCNAB2; OMA:KCNAB2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 5,990,927 bp[1] End 6,101,193 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 83.08 cM Start 152,475,199 bp[2] End 152,562,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 right frontal lobe pons cingulate gyrus anterior cingulate cortex granulocyte Brodmann area 9 nucleus accumbens amygdala spinal ganglia Top expressed in dentate gyrus of hippocampal formation granule cell neural layer of retina superior frontal gyrus hippocampus proper primary visual cortex primary motor cortex pontine nuclei lateral geniculate nucleus anterior horn of spinal cord medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aldo-keto reductase (NADP) activity voltage-gated ion channel activity potassium channel regulator activity voltage-gated potassium channel activity oxidoreductase activity Cellular component axon terminus cytoplasm integral component of membrane cytosol cell projection membrane postsynaptic density extrinsic component of cytoplasmic side of plasma membrane voltage-gated potassium channel complex plasma membrane synapse axon cell junction pinceau fiber neuron projection microtubule cytoskeleton juxtaparanode region of axon specific granule membrane tertiary granule membrane Biological process NADPH oxidation regulation of protein localization to cell surface regulation of ion transmembrane transport ion transport potassium ion transport neuromuscular process hematopoietic progenitor cell differentiation potassium ion transmembrane transport regulation of potassium ion transmembrane transport neutrophil degranulation ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8514 16498 Ensembl ENSG00000069424 ENSMUSG00000028931 UniProt Q13303 P62482 RefSeq (mRNA) NM_001199860 NM_001199861 NM_001199862 NM_001199863 NM_003636 NM_172130 NM_001252654 NM_001252655 NM_001252656 NM_010598 NM_001355172 NM_001355173 RefSeq (protein) NP_001186789 NP_001186790 NP_001186791 NP_001186792 NP_003627 NP_742128 NP_001186789.1 NP_001186790.1 NP_003627.1 NP_001239583 NP_001239584 NP_001239585 NP_034728 NP_001342101 NP_001342102 Location (UCSC) Chr 1: 5.99 – 6.1 Mb Chr 4: 152.48 – 152.56 Mb PubMed search [3] [4]
Wikidata
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Function

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.^[6]

In melanocytic cells KCNAB2 gene expression may be regulated by MITF.^[7]

Interactions

KCNAB2 has been shown to interact with KCNA2.^[8][9]

See also

• Voltage-gated potassium channel