KIF1B

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.^[5][6][7]

KIF1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EH0
Identifiers
Aliases	KIF1B, CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1, kinesin family member 1B
External IDs	OMIM: 605995; MGI: 108426; HomoloGene: 99835; GeneCards: KIF1B; OMA:KIF1B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 10,210,570 bp[1] End 10,381,603 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 79.05 cM Start 149,260,776 bp[2] End 149,392,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii internal globus pallidus Brodmann area 46 Skeletal muscle tissue of biceps brachii middle temporal gyrus ventricular zone pars reticulata Region I of hippocampus proper pars compacta Top expressed in retinal pigment epithelium neural layer of retina pontine nuclei dorsal tegmental nucleus ventral tegmental area habenula globus pallidus subiculum deep cerebellar nuclei dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule motor activity nucleotide binding microtubule binding ATPase activity protein binding kinesin binding ATP binding kinase binding scaffold protein binding plus-end-directed microtubule motor activity Cellular component cytoplasm kinesin complex microtubule associated complex mitochondrion neuron projection microtubule cytoskeleton cytoplasmic vesicle membrane cytoplasmic vesicle axon cytoplasm membrane axon dendrite Biological process cytoskeleton-dependent intracellular transport neuron-neuron synaptic transmission anterograde axonal transport microtubule-based movement neuromuscular synaptic transmission mitochondrion transport along microtubule apoptotic process positive regulation of gene expression transport along microtubule lysosome localization response to rotenone cellular response to nerve growth factor stimulus protein localization to cell periphery anterograde neuronal dense core vesicle transport retrograde neuronal dense core vesicle transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23095 16561 Ensembl ENSG00000054523 ENSMUSG00000063077 UniProt O60333 Q60575 RefSeq (mRNA) NM_183416 NM_015074 NM_001365951 NM_001365952 NM_001365953 NM_001290995 NM_008441 NM_207682 RefSeq (protein) NP_055889 NP_904325 NP_001352880 NP_001352881 NP_001352882 NP_001277924 NP_032467 NP_997565 Location (UCSC) Chr 1: 10.21 – 10.38 Mb Chr 4: 149.26 – 149.39 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

It is associated with Charcot–Marie–Tooth disease, type 2A1.^[7]

Interactions

KIF1B has been shown to interact with GIPC1.^[8]