GIPC1

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene.^[5][6][7] GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling.^[5] GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins. The human GIPC1 molecule is 333 amino acids or about 36 kDa in molecular size and consists of a central PDZ domain, a compact protein module which mediates specific protein-protein interactions. The RGS-GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule. As a result, GIPC1 was independently discovered by several other groups and has a variety of alternate names, including synectin, C19orf3, RGS19IP1 and others. The GIPC1 gene family in mammals consisting of three members, so the first discovered, originally named GIPC, is now generally called GIPC1, with the other two being named GIPC2 and GIPC3.^[8] The three human proteins are about 60% identical in protein sequence. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation.

GIPC1
Identifiers
Aliases	GIPC1, C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2, GIPC PDZ domain containing family member 1, OPDM2
External IDs	OMIM: 605072; MGI: 1926252; HomoloGene: 21167; GeneCards: GIPC1; OMA:GIPC1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,477,760 bp[1] End 14,496,149 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 84,379,306 bp[2] End 84,391,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of leg skin of abdomen C1 segment mucosa of pharynx apex of heart putamen minor salivary glands right frontal lobe nucleus accumbens Top expressed in lip corneal stroma superior surface of tongue ventricular zone lens neural tube perirhinal cortex superior frontal gyrus yolk sac entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding PDZ domain binding signaling receptor binding protein homodimerization activity myosin binding actin binding cadherin binding Cellular component cell cortex brush border endocytic vesicle extracellular exosome cytoplasm cytosol membrane synaptic vesicle vesicle membrane dendritic spine dendritic shaft cytoplasmic vesicle Schaffer collateral - CA1 synapse presynapse postsynapse glutamatergic synapse Biological process G protein-coupled receptor signaling pathway positive regulation of cytokinesis protein targeting positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein stability regulation of synaptic plasticity glutamate secretion negative regulation of proteasomal ubiquitin-dependent protein catabolic process endothelial cell migration chemical synaptic transmission positive regulation of melanin biosynthetic process cellular response to interleukin-7 regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10755 67903 Ensembl ENSG00000123159 ENSMUSG00000019433 UniProt O14908 Q9Z0G0 RefSeq (mRNA) NM_005716 NM_202467 NM_202468 NM_202469 NM_202470 NM_202494 NM_018771 RefSeq (protein) NP_005707 NP_974197 NP_974198 NP_974199 NP_974223 NP_061241 Location (UCSC) Chr 19: 14.48 – 14.5 Mb Chr 8: 84.38 – 84.39 Mb PubMed search [3] [4]
Wikidata
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Interactions

GIPC1 has been shown to interact with:

• Actinin, alpha 1,^[9]
• ADRB1,^[10]
• GLUT1,^[9]
• ITGA5,^[11]
• ITGA6,^[11]
• KIF1B,^[9]
• LRP1,^[12]
• LRP2,^[12][13][14]
• LHCGR,^[15]
• MYO6,^[16][17]
• RGS19,^[18]
• TPBG,^[19] and
• TYRP1.^[20]

See also

GIPC PDZ domain containing family, member 2, GIPC2

GIPC PDZ domain containing family, member 3, GIPC3