KIF4A

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.^[5][6]

KIF4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZFC, 6OYL, 3ZFD
Identifiers
Aliases	KIF4A, KIF4, KIF4G1, MRX100, kinesin family member 4A, XLID100
External IDs	OMIM: 300521; MGI: 108389; HomoloGene: 69022; GeneCards: KIF4A; OMA:KIF4A - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,290,104 bp[1] End 70,420,886 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X C3|X 43.72 cM Start 99,669,343 bp[2] End 99,770,820 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone ganglionic eminence gonad testicle bone marrow trabecular bone stromal cell of endometrium mucosa of transverse colon Top expressed in zygote primary oocyte otic placode genital tubercle otic vesicle secondary oocyte tail of embryo saccule ventricular zone fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding microtubule motor activity nucleotide binding microtubule binding protein binding ATP binding plus-end-directed microtubule motor activity ATPase activity Cellular component cytosol membrane kinesin complex nuclear matrix spindle nucleoplasm chromosome spindle microtubule microtubule cytoskeleton nucleus axon cytoplasm midbody cytoplasm intercellular bridge Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle midzone assembly mitotic cytokinesis organelle organization anterograde axonal transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum microtubule-based movement mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24137 16571 Ensembl ENSG00000090889 ENSMUSG00000034311 UniProt O95239 P33174 RefSeq (mRNA) NM_012310 NM_008446 RefSeq (protein) NP_036442 NP_032472 Location (UCSC) Chr X: 70.29 – 70.42 Mb Chr X: 99.67 – 99.77 Mb PubMed search [3] [4]
Wikidata
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Function

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.^[6]

Interactions

KIF4A has been shown to interact with HMG20B^[7] and DNMT3B.^[8]

Clinical significance

NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV).^[9] KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.^[10]