HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.^[5][6]

HMG20B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRJ
Identifiers
Aliases	HMG20B, BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857, high mobility group 20B
External IDs	OMIM: 605535; MGI: 1341190; HomoloGene: 74949; GeneCards: HMG20B; OMA:HMG20B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,572,777 bp[1] End 3,579,088 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,181,882 bp[2] End 81,186,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium olfactory zone of nasal mucosa skin of leg muscle layer of sigmoid colon canal of the cervix popliteal artery tibial arteries skin of abdomen right uterine tube Top expressed in interventricular septum lip yolk sac genital tubercle granulocyte ventricular zone lens internal carotid artery tail of embryo duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding protein binding histone deacetylase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm chromosome nuclear body Biological process skeletal muscle cell differentiation cell cycle negative regulation of protein sumoylation blood coagulation regulation of transcription, DNA-templated positive regulation of neuron differentiation transcription, DNA-templated histone deacetylation chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10362 15353 Ensembl ENSG00000064961 ENSMUSG00000020232 UniProt Q9P0W2 Q9Z104 RefSeq (mRNA) NM_006339 NM_001163165 NM_001163166 NM_010440 RefSeq (protein) NP_006330 NP_001156637 NP_001156638 NP_034570 Location (UCSC) Chr 19: 3.57 – 3.58 Mb Chr 10: 81.18 – 81.19 Mb PubMed search [3] [4]
Wikidata
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HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis^[7] This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins.^[7]

Interactions

HMG20B has been shown to interact with:

• BRCA2,^[8][9]
• HDAC1,^[8]
• HDAC2,^[8][10]
• KIF4A,^[11]
• PHF21A,^[8][12] and
• RCOR1.^[8]