KIF5B

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene.^[5][6] It is part of the kinesin family of motor proteins.

KIF5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BG2, 1MKJ, 2P4N, 3J8X, 3J8Y, 4HNA, 4LNU
Identifiers
Aliases	KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC, kinesin family member 5B
External IDs	OMIM: 602809; MGI: 1098268; HomoloGene: 55829; GeneCards: KIF5B; OMA:KIF5B - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.22 Start 32,009,015 bp[1] End 32,056,425 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A1|18 4.46 cM Start 6,201,002 bp[2] End 6,242,174 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis caput epididymis optic nerve corpus epididymis mucosa of paranasal sinus inferior ganglion of vagus nerve visceral pleura lower lobe of lung internal globus pallidus Skeletal muscle tissue of biceps brachii Top expressed in globus pallidus lateral geniculate nucleus atrioventricular valve ventral tegmental area pontine nuclei epithelium of lens lateral hypothalamus deep cerebellar nuclei seminal vesicula epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity nucleotide binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding JUN kinase binding cadherin binding microtubule lateral binding identical protein binding ATPase activity Cellular component vesicle membrane kinesin complex endocytic vesicle microtubule organizing center membrane-bounded organelle ciliary rootlet perinuclear region of cytoplasm neuron projection microtubule cytoskeleton axonal growth cone cytoplasm cytosol microtubule cytoskeleton phagocytic vesicle axon cytoplasm Biological process cytoskeleton-dependent intracellular transport plus-end-directed vesicle transport along microtubule cytoplasm organization vesicle transport along microtubule positive regulation of potassium ion transport regulation of membrane potential positive regulation of synaptic transmission, GABAergic axon guidance microtubule-based movement stress granule disassembly positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of intracellular protein transport positive regulation of voltage-gated sodium channel activity positive regulation of vesicle fusion centrosome localization brain development hippocampus development positive regulation of protein localization to plasma membrane cellular response to interferon-gamma anterograde axonal protein transport anterograde neuronal dense core vesicle transport retrograde neuronal dense core vesicle transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3799 16573 Ensembl ENSG00000170759 ENSMUSG00000006740 UniProt P33176 Q61768 RefSeq (mRNA) NM_004521 NM_008448 RefSeq (protein) NP_004512 NP_032474 Location (UCSC) Chr 10: 32.01 – 32.06 Mb Chr 18: 6.2 – 6.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

KIF5B has been shown to interact with:

• KLC1,^[7][8][9]
• KLC2,^[8][9]
• SNAP-25,^[7]
• SNAP23,^[7] and
• YWHAH.^[10]