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KLC2
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.[5][6] This gene is responsible for SPOAN syndrome, a type of hereditary spastic paraplegia.[7][8]
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Interactions
KLC2 has been shown to interact with MAPK8IP3[9] and KIF5B.[5][10]
SPOAN syndrome
SPOAN syndrome was first discovered by a research group led by Silvana Santos in the Serrinha dos Pintos area of Northeast Brazil known for high levels of inbreeding.[11] The name derives from an acronym for spastic paraplegia, optic atrophy, and peripheral neuropathy (SPOAN), the symptoms characteristic to the syndrome.[7] The cause is a homozygous deletion of 216 base pairs in KLC2 regulatory region.[12] This homozygous deletion has been found in more than 70 individuals from Rio Grande do Norte backlands and siblings in Egypt; the mutation origin was in Iberian Peninsula over 485 years ago.[13]
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References
Further reading
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