KLF5

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.^[5][6]

KLF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBT
Identifiers
Aliases	KLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDs	OMIM: 602903; MGI: 1338056; HomoloGene: 37520; GeneCards: KLF5; OMA:KLF5 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q22.1 Start 73,054,976 bp[1] End 73,077,541 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E2.2 Start 99,536,127 bp[2] End 99,552,472 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx gingival epithelium human penis mucosa of pharynx amniotic fluid mucosa of nose mucosa of sigmoid colon nipple skin of abdomen olfactory zone of nasal mucosa Top expressed in left colon crypt of lieberkuhn of small intestine gastrula mucosa of urinary bladder transitional epithelium of urinary bladder migratory enteric neural crest cell skin of external ear conjunctival fornix ileum Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding nucleic acid binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding MRF binding Cellular component Golgi apparatus intracellular membrane-bounded organelle nucleoplasm nucleus transcription regulator complex Biological process regulation of microvillus assembly microvillus assembly regulation of transcription, DNA-templated intestinal epithelial cell development regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated angiogenesis skeletal muscle cell differentiation positive regulation of fat cell differentiation positive regulation of transcription by RNA polymerase II cellular response to organic cyclic compound positive regulation of cell population proliferation cellular response to peptide cellular response to leukemia inhibitory factor cell-cell signaling via exosome positive regulation of pri-miRNA transcription by RNA polymerase II regulation of gene expression skeletal muscle satellite cell differentiation satellite cell activation involved in skeletal muscle regeneration myotube differentiation involved in skeletal muscle regeneration skeletal muscle tissue regeneration positive regulation of transcription by transcription factor localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 688 12224 Ensembl ENSG00000102554 ENSMUSG00000005148 UniProt Q13887 Q9Z0Z7 RefSeq (mRNA) NM_001730 NM_001286818 NM_009769 RefSeq (protein) NP_001273747 NP_001721 NP_033899 Location (UCSC) Chr 13: 73.05 – 73.08 Mb Chr 14: 99.54 – 99.55 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.^[6]

Interactions

KLF5 has been shown to interact with Protein SET.^[7]

Clinical significance

KLF5 expression has been linked to higher survival rates for lung cancer patients.^[8]

See also

• Kruppel-like factors