Protein SET

Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the SET gene.^[5][6][7]

SET
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E50
Identifiers
Aliases	SET, 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, SET nuclear proto-oncogene, MRD58
External IDs	OMIM: 600960; MGI: 1860267; HomoloGene: 55707; GeneCards: SET; OMA:SET - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,683,424 bp[1] End 128,696,400 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 29,947,390 bp[2] End 29,962,589 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon ventricular zone epithelium of nasopharynx epithelium of colon germinal epithelium palpebral conjunctiva lymph node optic nerve parietal pleura Top expressed in tail of embryo epiblast abdominal wall migratory enteric neural crest cell morula ventricular zone embryo vas deferens primitive streak somite More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding histone binding protein binding protein phosphatase inhibitor activity protein phosphatase regulator activity Cellular component cytoplasm cytosol nucleoplasm endoplasmic reticulum perinuclear region of cytoplasm nucleus lipid droplet protein-containing complex Biological process negative regulation of neuron apoptotic process nucleosome assembly regulation of mRNA stability DNA replication nucleosome disassembly nucleocytoplasmic transport viral process negative regulation of transcription, DNA-templated negative regulation of histone acetylation negative regulation of catalytic activity regulation of catalytic activity negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6418 56086 Ensembl ENSG00000119335 ENSMUSG00000054766 UniProt Q01105 Q9EQU5 RefSeq (mRNA) NM_001122821 NM_001248000 NM_001248001 NM_003011 NM_001374326 NM_001204875 NM_023871 RefSeq (protein) NP_001116293 NP_001234929 NP_001234930 NP_003002 NP_001361255 NP_001191804 NP_076360 Location (UCSC) Chr 9: 128.68 – 128.7 Mb Chr 2: 29.95 – 29.96 Mb PubMed search [3] [4]
Wikidata
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Interactions

Protein SET has been shown to interact with:

• Acidic leucine-rich nuclear phosphoprotein 32 family member A,^[8][9]
• CDK5R1,^[10]
• KLF5,^[11]
• NME1,^[12] and
• TAF1A.^[8]