KPNB1

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.^[5][6]

KPNB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F59, 1IBR, 1M5N, 1O6O, 1O6P, 1QGK, 1QGR, 2P8Q, 2Q5D, 2QNA, 3LWW, 3W5K
Identifiers
Aliases	KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1
External IDs	OMIM: 602738; MGI: 107532; HomoloGene: 1707; GeneCards: KPNB1; OMA:KPNB1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,649,476 bp[1] End 47,685,505 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 97,050,540 bp[2] End 97,078,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell ventricular zone ganglionic eminence optic nerve secondary oocyte islet of Langerhans tendon of biceps brachii stromal cell of endometrium internal globus pallidus appendix Top expressed in tail of embryo condyle fossa epiblast genital tubercle primitive streak medullary collecting duct abdominal wall ureter ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Hsp90 protein binding protein domain specific binding zinc ion binding protein binding nuclear localization sequence binding enzyme binding RNA binding importin-alpha family protein binding Cellular component nuclear membrane membrane nuclear periphery nuclear pore endoplasmic reticulum tubular network nucleoplasm extracellular exosome nucleus nuclear envelope extracellular region cytoplasm cytosol specific granule lumen ficolin-1-rich granule lumen host cell cytoplasmic stress granule protein-containing complex Biological process intracellular transport of virus apoptotic DNA fragmentation Ran protein signal transduction establishment of protein localization mitotic spindle assembly protein transport mitotic metaphase plate congression intracellular protein transport astral microtubule organization mitotic chromosome movement towards spindle pole establishment of mitotic spindle localization NLS-bearing protein import into nucleus modulation by virus of host cellular process protein import into nucleus ribosomal protein import into nucleus viral process neutrophil degranulation regulation of cholesterol biosynthetic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3837 16211 Ensembl ENSG00000108424 ENSMUSG00000001440 UniProt Q14974 P70168 RefSeq (mRNA) NM_002265 NM_001276453 NM_008379 RefSeq (protein) NP_001263382 NP_002256 NP_032405 Location (UCSC) Chr 17: 47.65 – 47.69 Mb Chr 11: 97.05 – 97.08 Mb PubMed search [3] [4]
Wikidata
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Function

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits. Each of these subunits are part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.^[7]

Interactions

KPNB1 has been shown to interact with:

• KPNA3,^[8][9]
• Karyopherin alpha 1,^[8][10]
• Karyopherin alpha 2,^[8][11][12]
• Mothers against decapentaplegic homolog 3,^[13]
• NUP153^[14][15][16]
• NUP50,^[17]
• NUP98,^[18][19]
• Nucleoporin 62,^[10][14]
• P53,^[20]
• Parathyroid hormone-related protein,^[21][22]
• RANBP1,^[23][24]
• RANBP2,^[14][23][25]
• Ran (biology),^[10][24][26] and
• SMN1.^[27]