Importin subunit alpha-5

Importin subunit alpha-5 is a protein that in humans is encoded by the KPNA1 gene.^[5]

KPNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JDQ, 3TJ3, 4B18
Identifiers
Aliases	KPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1
External IDs	OMIM: 600686; MGI: 103560; HomoloGene: 55642; GeneCards: KPNA1; OMA:KPNA1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.1 Start 122,421,902 bp[1] End 122,514,945 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 35,799,120 bp[2] End 35,857,501 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes biceps brachii sural nerve deltoid muscle gastrocnemius muscle endothelial cell Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis triceps brachii muscle tibialis anterior muscle Top expressed in triceps brachii muscle otic vesicle gastrocnemius muscle vastus lateralis muscle muscle of thigh extensor digitorum longus muscle medial head of gastrocnemius muscle temporal muscle blood sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding nuclear import signal receptor activity Cellular component nuclear pore nucleoplasm dendrite nucleus cytoplasm cytosol host cell postsynaptic density glutamatergic synapse Biological process regulation of DNA recombination intracellular transport of virus apoptotic DNA fragmentation protein import into nucleus protein transport modulation by virus of host cellular process NLS-bearing protein import into nucleus viral process postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3836 16646 Ensembl ENSG00000114030 ENSMUSG00000022905 UniProt P52294 Q60960 RefSeq (mRNA) NM_002264 NM_008465 RefSeq (protein) NP_002255 NP_032491 Location (UCSC) Chr 3: 122.42 – 122.51 Mb Chr 16: 35.8 – 35.86 Mb PubMed search [3] [4]
Wikidata
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Interactions

Importin subunit alpha-5 has been shown to interact with KPNB1^[6][7] and UBR5.^[8]