UBR5

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.^[5][6][7]

UBR5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I2T, 2QHO, 3PT3
Identifiers
Aliases	UBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 5
External IDs	OMIM: 608413; MGI: 1918040; HomoloGene: 9295; GeneCards: UBR5; OMA:UBR5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 102,252,273 bp[1] End 102,412,759 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 37,967,572 bp[2] End 38,079,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone sural nerve ganglionic eminence epithelium of colon Achilles tendon left testis gastric mucosa right testis skin of abdomen skin of leg Top expressed in genital tubercle tail of embryo saccule spermatocyte neural layer of retina otic placode spermatid otic vesicle cumulus cell ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity ubiquitin-ubiquitin ligase activity ubiquitin binding protein binding RNA binding zinc ion binding metal ion binding transferase activity ubiquitin protein ligase activity Cellular component nucleus nucleoplasm membrane cytosol perinuclear region of cytoplasm protein-containing complex Biological process negative regulation of double-strand break repair negative regulation of histone H2A K63-linked ubiquitination protein polyubiquitination progesterone receptor signaling pathway cellular response to DNA damage stimulus ubiquitin-dependent protein catabolic process positive regulation of canonical Wnt signaling pathway protein ubiquitination cell population proliferation DNA repair positive regulation of gene expression viral process protein K48-linked ubiquitination positive regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51366 70790 Ensembl ENSG00000104517 ENSMUSG00000037487 UniProt O95071 Q80TP3 RefSeq (mRNA) NM_001282873 NM_015902 NM_001081359 NM_001112721 NM_027553 RefSeq (protein) NP_001269802 NP_056986 NP_001074828 NP_001106192 Location (UCSC) Chr 8: 102.25 – 102.41 Mb Chr 15: 37.97 – 38.08 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.^[7]

Interactions

UBR5 has been shown to interact with:

• CIB1,^[8]
• Karyopherin alpha 1,^[8]
• MAPK1,^[9] and
• TOPBP1.^[10]