LATS1

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.^[5][6][7]

LATS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZRK, 5BRK, 5B5W
Identifiers
Aliases	LATS1, WARTS, wts, large tumor suppressor kinase 1
External IDs	OMIM: 603473; MGI: 1333883; HomoloGene: 55843; GeneCards: LATS1; OMA:LATS1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,658,153 bp[1] End 149,718,105 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 7,556,978 bp[2] End 7,592,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium tibia mucosa of paranasal sinus gingival epithelium epithelium of nasopharynx parietal pleura visceral pleura seminal vesicula retinal pigment epithelium palpebral conjunctiva Top expressed in genital tubercle tail of embryo uterus ganglionic eminence ventricular zone ovary lens jejunum granulocyte ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding protein kinase binding protein kinase activity kinase activity transferase activity metal ion binding magnesium ion binding protein serine/threonine kinase activity ATP binding estrogen receptor binding Cellular component microtubule organizing center spindle pole cytoplasm cytoskeleton cytosol Biological process cell cycle phosphorylation G2/M transition of mitotic cell cycle regulation of actin filament polymerization inner cell mass cell fate commitment keratinocyte differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity regulation of organ growth regulation of protein-containing complex assembly cytoplasmic sequestering of protein sister chromatid segregation positive regulation of apoptotic process negative regulation of canonical Wnt signaling pathway inner cell mass cellular morphogenesis cell division positive regulation of peptidyl-serine phosphorylation hippo signaling protein phosphorylation hormone-mediated signaling pathway regulation of intracellular estrogen receptor signaling pathway mammary gland epithelial cell differentiation regulation of ubiquitin-dependent protein catabolic process mitotic cell cycle G1/S transition of mitotic cell cycle peptidyl-serine phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9113 16798 Ensembl ENSG00000131023 ENSMUSG00000040021 UniProt O95835 Q6PJG3 Q8BYR2 RefSeq (mRNA) NM_001270519 NM_004690 NM_001350339 NM_001350340 NM_001350392 NM_010690 RefSeq (protein) NP_001257448 NP_004681 NP_001337268 NP_001337269 NP_001337321 NP_034820 Location (UCSC) Chr 6: 149.66 – 149.72 Mb Chr 10: 7.56 – 7.59 Mb PubMed search [3] [4]
Wikidata
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It has been associated with the Hippo signaling pathway, where it phosphorylates YAP and TAZ to inactivate their function.^[8]

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced histone H1 kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.^[7]

Interactions

LATS1 has been shown to interact with Zyxin^[9] and Cdk1.^[5]