LDB1

LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.^[5][6][7]

LDB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XJY, 2XJZ, 2YPA
Identifiers
Aliases	LDB1, CLIM2, NLI, CLIM-2, LDB-1, LIM domain binding 1
External IDs	OMIM: 603451; MGI: 894762; HomoloGene: 2891; GeneCards: LDB1; OMA:LDB1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 102,106,489 bp[1] End 102,120,368 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 38.75 cM Start 46,020,009 bp[2] End 46,033,653 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence left ovary skin of leg gastric mucosa skin of abdomen right ovary canal of the cervix sural nerve body of uterus Top expressed in ventricular zone tail of embryo lip genital tubercle thymus epiblast yolk sac superior frontal gyrus dentate gyrus of hippocampal formation granule cell neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein homodimerization activity transcription corepressor activity LIM domain binding chromatin binding protein self-association protein binding cis-regulatory region sequence-specific DNA binding enzyme binding transcription coregulator activity Cellular component transcription regulator complex nucleus cell leading edge nucleoplasm beta-catenin-TCF complex protein-containing complex Biological process hair follicle development transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery epithelial structure maintenance regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process somatic stem cell population maintenance regulation of transcription by RNA polymerase II gastrulation with mouth forming second cerebellar Purkinje cell differentiation regulation of DNA-templated transcription, elongation head development histone H3-K4 acetylation Wnt signaling pathway transcription by RNA polymerase II transcription, DNA-templated cerebellum development negative regulation of erythrocyte differentiation multicellular organism development neuron differentiation anterior/posterior axis specification cellular component assembly negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of cell adhesion regulation of focal adhesion assembly regulation of cell migration regulation of kinase activity regulation of hematopoietic stem cell differentiation negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8861 16825 Ensembl ENSG00000198728 ENSMUSG00000025223 UniProt Q86U70 P70662 RefSeq (mRNA) NM_001113407 NM_003893 NM_001321612 NM_001113408 NM_010697 NM_001360336 RefSeq (protein) NP_001106878 NP_001308541 NP_003884 NP_001106879 NP_034827 NP_001347265 Location (UCSC) Chr 10: 102.11 – 102.12 Mb Chr 19: 46.02 – 46.03 Mb PubMed search [3] [4]
Wikidata
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Interactions

LDB1 has been shown to interact with other proteins such as LMO4,^[8][9] TCF3,^[10] TAL1^[10] and CBFA2T3.^[10]