TAL1

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.^[5][6]

TAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDs	OMIM: 187040; MGI: 98480; HomoloGene: 2400; GeneCards: TAL1; OMA:TAL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33 Start 47,216,290 bp[1] End 47,232,225 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D1|4 52.73 cM Start 114,913,623 bp[2] End 114,928,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone monocyte bone marrow right lung endothelial cell blood upper lobe of left lung bone marrow cells buccal mucosa cell epithelium of colon Top expressed in fetal liver hematopoietic progenitor cell tibiofemoral joint blood human fetus embryo spleen endocardial cushion bone marrow yolk sac genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity DNA-binding transcription factor activity histone deacetylase binding chromatin binding transcription cis-regulatory region binding E-box binding protein binding protein heterodimerization activity enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component histone deacetylase complex transcription regulator complex Lsd1/2 complex nucleus nucleoplasm protein-containing complex Biological process megakaryocyte development megakaryocyte differentiation myeloid cell differentiation cell fate commitment cell differentiation regulation of transcription, DNA-templated regulation of mast cell differentiation spinal cord association neuron differentiation positive regulation of protein-containing complex assembly locomotory behavior positive regulation of erythrocyte differentiation regulation of transcription by RNA polymerase II regulation of stem cell population maintenance platelet formation positive regulation of mitotic cell cycle negative regulation of transcription by RNA polymerase II transcription, DNA-templated generation of neurons basophil differentiation positive regulation of transcription, DNA-templated multicellular organism development regulation of cell population proliferation hematopoietic stem cell differentiation astrocyte fate commitment angiogenesis neuron differentiation embryonic hemopoiesis erythrocyte differentiation definitive hemopoiesis regulation of myeloid cell differentiation positive regulation of cell division hemangioblast cell differentiation positive regulation of transcription by RNA polymerase II erythrocyte maturation regulation of hematopoietic stem cell differentiation hemopoiesis transcription by RNA polymerase II negative regulation of erythrocyte differentiation positive regulation of protein tyrosine kinase activity positive regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6886 21349 Ensembl ENSG00000162367 ENSMUSG00000028717 UniProt P17542 P22091 RefSeq (mRNA) NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189 NM_011527 NM_001287388 RefSeq (protein) NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335 NP_003180 NP_001274317 NP_035657 Location (UCSC) Chr 1: 47.22 – 47.23 Mb Chr 4: 114.91 – 114.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

• CBFA2T3,^[7]
• EP300,^[8]
• GATA1,^[7][9]
• LDB1,^[7]
• LMO1,^[10][11]
• LMO2,^{[7][9][10][11]}
• SIN3A,^[12]
• Sp1 transcription factor,^[13] and
• TCF3.^[7][14]