LIN7B

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^[5][6]

LIN7B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DKR
Identifiers
Aliases	LIN7B, LIN-7B, MALS-2, MALS2, VELI2, lin-7 homolog B, crumbs cell polarity complex component
External IDs	OMIM: 612331; MGI: 1330858; HomoloGene: 22648; GeneCards: LIN7B; OMA:LIN7B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,114,324 bp[1] End 49,118,460 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,017,315 bp[2] End 45,020,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior cingulate cortex endothelial cell right frontal lobe nucleus accumbens Brodmann area 9 anterior pituitary prefrontal cortex Amygdala caudate nucleus putamen Top expressed in facial motor nucleus motor neuron superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex substantia nigra barrel cortex primary motor cortex anterior amygdaloid area Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein domain specific binding L27 domain binding protein binding Cellular component postsynaptic membrane postsynaptic density membrane cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection presynapse synapse MPP7-DLG1-LIN7 complex Biological process protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport neurotransmitter secretion exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64130 22342 Ensembl ENSG00000104863 ENSMUSG00000003872 UniProt Q9HAP6 O88951 RefSeq (mRNA) NM_001308419 NM_022165 NM_011698 RefSeq (protein) NP_001295348 NP_071448 NP_035828 Location (UCSC) Chr 19: 49.11 – 49.12 Mb Chr 7: 45.02 – 45.02 Mb PubMed search [3] [4]
Wikidata
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Interactions

LIN7B has been shown to interact with:

• ACCN3,^[7]
• GRIN2B,^[5]
• KCNJ12^[8][9] and
• KCNJ4.^[10]