LMO1

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.^[5][6][7]

LMO1
Identifiers
Aliases	LMO1, RBTN1, RHOM1, TTG1, LIM domain only 1
External IDs	OMIM: 186921; MGI: 102812; HomoloGene: 48101; GeneCards: LMO1; OMA:LMO1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 8,224,309 bp[1] End 8,268,716 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.21 cM Start 108,737,779 bp[2] End 108,774,414 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad vastus lateralis muscle muscle of thigh oocyte testicle retinal pigment epithelium secondary oocyte biceps brachii islet of Langerhans gastrocnemius muscle Top expressed in medial ganglionic eminence wall of urinary bladder mucosa of urinary bladder transitional epithelium of urinary bladder primary oocyte zygote lip secondary oocyte facial motor nucleus superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component nucleus nucleoplasm Biological process regulation of T cell homeostatic proliferation negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4004 109594 Ensembl ENSG00000166407 ENSMUSG00000036111 UniProt P25800 Q924W9 RefSeq (mRNA) NM_001270428 NM_002315 NM_001302205 NM_001302206 NM_057173 NM_001382564 RefSeq (protein) NP_001257357 NP_002306 NP_001289134 NP_001289135 NP_476514 NP_001369493 Location (UCSC) Chr 11: 8.22 – 8.27 Mb Chr 7: 108.74 – 108.77 Mb PubMed search [3] [4]
Wikidata
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LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.^[7]

Interactions

LMO1 has been shown to interact with GATA3^[8][9] and TAL1.^[10][11]