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LMX1A

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

LMX1A
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LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[5][6]

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Function

Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[7]

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Interactions

LMX1A has been shown to interact with TCF3[8] and LHX3.[9]

References

Further reading

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