LSM1

U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.^[4][5][6]

LSM1
Identifiers
Aliases	LSM1, CASM, YJL124C, LSM1 homolog, mRNA degradation associated
External IDs	OMIM: 607281; MGI: 1914457; HomoloGene: 40945; GeneCards: LSM1; OMA:LSM1 - orthologs
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8|8 A2 Start 26,275,316 bp[1] End 26,294,003 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland hair follicle right ventricle renal medulla saphenous vein cardia monocyte vena cava external globus pallidus body of tongue Top expressed in renal corpuscle medullary collecting duct epithelium of lens facial motor nucleus medial ganglionic eminence embryo neural tube ectoderm epiblast otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA cap binding pre-mRNA binding mRNA binding RNA binding Cellular component cytosol P-body messenger ribonucleoprotein complex axon soma dendrite nucleus cytoplasm mRNA cap binding complex Lsm1-7-Pat1 complex Biological process negative regulation of neuron differentiation deadenylation-dependent decapping of nuclear-transcribed mRNA RNA splicing, via transesterification reactions mRNA processing stem cell population maintenance RNA splicing exonucleolytic catabolism of deadenylated mRNA histone mRNA catabolic process nuclear-transcribed mRNA catabolic process RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27257 67207 Ensembl n/a ENSMUSG00000037296 UniProt O15116 Q8VC85 RefSeq (mRNA) NM_014462 NM_026032 RefSeq (protein) NP_055277 NP_080308 Location (UCSC) n/a Chr 8: 26.28 – 26.29 Mb PubMed search [2] [3]
Wikidata
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Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.^[6]