Small nuclear ribonucleoprotein D2

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene.^[5][6][7] It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.^[7]

SNRPD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B34, 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPD2, SMD2, SNRPD1, Sm-D2, Small nuclear ribonucleoprotein D2, small nuclear ribonucleoprotein D2 polypeptide
External IDs	OMIM: 601061; MGI: 98345; HomoloGene: 3381; GeneCards: SNRPD2; OMA:SNRPD2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,687,460 bp[1] End 45,692,569 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 18,883,647 bp[2] End 18,887,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell embryo corpus epididymis oral cavity left ovary ganglionic eminence tail of epididymis caput epididymis superficial temporal artery vulva Top expressed in yolk sac synovial joint urinary bladder ankle joint embryo ventricular zone embryo lens epiblast ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding U1 snRNP binding Cellular component cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U4/U6 x U5 tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex spliceosomal complex U4 snRNP extracellular exosome nucleus U1 snRNP U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly RNA splicing import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6633 107686 Ensembl ENSG00000125743 ENSMUSG00000040824 UniProt P62316 P62317 RefSeq (mRNA) NM_004597 NM_177542 NM_001369751 NM_001369752 NM_001384647 NM_026943 RefSeq (protein) NP_004588 NP_808210 NP_001356680 NP_001356681 NP_081219 Location (UCSC) Chr 19: 45.69 – 45.69 Mb Chr 7: 18.88 – 18.89 Mb PubMed search [3] [4]
Wikidata
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Interactions

Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20,^[8] Small nuclear ribonucleoprotein D1,^[9][10] Small nuclear ribonucleoprotein polypeptide F,^[9] CDC5L^[11] and SMN1.^[12]