LSM3

U6 snRNA-associated Sm-like protein LSm3 is a protein that in humans is encoded by the LSM3 gene.^[5][6]

LSM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM3, SMX4, USS2, YLR438C, LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607283; MGI: 1914928; HomoloGene: 6548; GeneCards: LSM3; OMA:LSM3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 14,178,817 bp[1] End 14,201,122 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 91,492,910 bp[2] End 91,499,607 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii thoracic diaphragm right ventricle beta cell oral cavity triceps brachii muscle mucosa of sigmoid colon Skeletal muscle tissue of rectus abdominis trabecular bone Top expressed in epiblast embryo embryo blastocyst yolk sac ventricular zone primary oocyte thymus placenta bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component U6 snRNP cytosol Lsm1-7-Pat1 complex catalytic step 2 spliceosome P-body U4/U6 x U5 tri-snRNP complex spliceosomal complex precatalytic spliceosome nucleus nucleoplasm U2-type precatalytic spliceosome Lsm2-8 complex Biological process mRNA processing P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA splicing mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27258 67678 Ensembl ENSG00000170860 ENSMUSG00000034192 UniProt P62310 P62311 RefSeq (mRNA) NM_014463 NM_026309 RefSeq (protein) NP_055278 NP_080585 Location (UCSC) Chr 3: 14.18 – 14.2 Mb Chr 6: 91.49 – 91.5 Mb PubMed search [3] [4]
Wikidata
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Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[6]

Interactions

LSM3 has been shown to interact with LSM2^{[7][8][9][10]} and LSM10.^[7][9]