LSM2

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.^[5][6][7]

LSM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM2, C6orf28, G7B, YBL026W, snRNP, LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607282; MGI: 90676; HomoloGene: 48535; GeneCards: LSM2; OMA:LSM2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,797,396 bp[1] End 31,806,966 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.52 cM Start 35,200,838 bp[2] End 35,204,867 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad mucosa of transverse colon body of uterus canal of the cervix myometrium left uterine tube muscle layer of sigmoid colon ectocervix Top expressed in genital tubercle tail of embryo yolk sac embryo embryo spermatocyte spermatid epiblast seminiferous tubule ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding U6 snRNA binding RNA binding Cellular component cytosol U4/U6 x U5 tri-snRNP complex catalytic step 2 spliceosome U6 snRNP P-body nucleoplasm Lsm1-7-Pat1 complex precatalytic spliceosome spliceosomal complex nucleus U2-type precatalytic spliceosome Lsm2-8 complex Biological process mRNA splicing, via spliceosome mRNA processing exonucleolytic catabolism of deadenylated mRNA RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57819 27756 Ensembl ENSG00000204392 ENSMUSG00000007050 UniProt Q9Y333 O35900 RefSeq (mRNA) NM_021177 NM_001110101 NM_001204273 NM_001204274 NM_030597 RefSeq (protein) NP_067000 NP_001103571 NP_001191202 NP_001191203 NP_085100 Location (UCSC) Chr 6: 31.8 – 31.81 Mb Chr 17: 35.2 – 35.2 Mb PubMed search [3] [4]
Wikidata
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Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]

Interactions

LSM2 has been shown to interact with DDX20,^[8] LSM3,^{[9][10][11][12]} LSM8^[9][10] and LSM7.^[9][10]