LSM6

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.^[5][6][7]

LSM6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM6, YDR378C, LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607286; MGI: 1925901; HomoloGene: 38271; GeneCards: LSM6; OMA:LSM6 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.22 Start 146,175,703 bp[1] End 146,200,000 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 79,531,494 bp[2] End 79,547,769 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte appendix lymph node Achilles tendon abdominal fat ganglionic eminence mucosa of transverse colon right lung islet of Langerhans Top expressed in hand endocardial cushion atrioventricular valve abdominal wall embryo dermis embryo ventricular zone epiblast otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm cytosol nucleoplasm small nuclear ribonucleoprotein complex spliceosomal complex extracellular exosome nucleus P-body U6 snRNP nucleolus sno(s)RNA-containing ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome Lsm2-8 complex Biological process tRNA processing mRNA processing RNA splicing exonucleolytic catabolism of deadenylated mRNA rRNA processing mRNA splicing, via spliceosome maturation of SSU-rRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11157 78651 Ensembl ENSG00000164167 ENSMUSG00000031683 UniProt P62312 P62313 RefSeq (mRNA) NM_007080 NM_001191004 NM_030145 RefSeq (protein) NP_009011 NP_001177933 NP_084421 Location (UCSC) Chr 4: 146.18 – 146.2 Mb Chr 8: 79.53 – 79.55 Mb PubMed search [3] [4]
Wikidata
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Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop.

The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]