LSM8

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.^[5][6]

LSM8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM8, NAA38, LSM8 homolog, U6 small nuclear RNA associated
External IDs	OMIM: 607288; MGI: 1923772; HomoloGene: 9419; GeneCards: LSM8; OMA:LSM8 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.31 Start 118,184,144 bp[1] End 118,204,035 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A2 Start 18,848,578 bp[2] End 18,855,750 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon right ventricle ventricular zone monocyte bone marrow bone marrow cells skin of thigh granulocyte oocyte Top expressed in primitive streak abdominal wall medial ganglionic eminence hair follicle vas deferens embryo migratory enteric neural crest cell mandibular prominence Gonadal ridge embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding U6 snRNA binding RNA binding Cellular component spliceosomal complex nucleus nucleoplasm U4/U6 x U5 tri-snRNP complex U6 snRNP precatalytic spliceosome U2-type precatalytic spliceosome Lsm2-8 complex Biological process mRNA processing RNA splicing mRNA splicing, via spliceosome RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51691 76522 Ensembl ENSG00000128534 ENSMUSG00000044155 UniProt O95777 Q6ZWM4 RefSeq (mRNA) NM_016200 NM_133939 RefSeq (protein) NP_057284 NP_598700 Location (UCSC) Chr 7: 118.18 – 118.2 Mb Chr 6: 18.85 – 18.86 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.^[6]

Interactions

LSM8 has been shown to interact with LSM2.^[7][8]