Laminin subunit alpha-1

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.^[5][6]

LAMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JD4
Identifiers
Aliases	LAMA1, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
External IDs	OMIM: 150320; MGI: 99892; HomoloGene: 21146; GeneCards: LAMA1; OMA:LAMA1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.31 Start 6,941,742 bp[1] End 7,117,797 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.1|17 38.8 cM Start 68,004,254 bp[2] End 68,129,642 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone right testis left testis mucosa of ileum gonad stromal cell of endometrium testicle ganglionic eminence mucosa of colon mucosa of sigmoid colon Top expressed in Bowman's capsule tail of embryo ovary epithelium of lens cumulus cell inner renal medulla Gonadal ridge efferent ductule yolk sac cortical collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding extracellular matrix structural constituent protein binding protein C-terminus binding glycosphingolipid binding Cellular component extracellular matrix extracellular region basement membrane laminin-1 complex laminin-3 complex extracellular space membrane cell-cell junction laminin complex collagen-containing extracellular matrix Biological process cell surface receptor signaling pathway regulation of cell adhesion cell adhesion extracellular matrix organization regulation of cell migration regulation of embryonic development morphogenesis of an epithelial sheet protein phosphorylation tissue development neuron projection development establishment of epithelial cell apical/basal polarity retina development in camera-type eye epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis retinal blood vessel morphogenesis axon guidance animal organ morphogenesis camera-type eye development blood vessel morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284217 16772 Ensembl ENSG00000101680 ENSMUSG00000032796 UniProt P25391 P19137 RefSeq (mRNA) NM_005559 NM_008480 RefSeq (protein) NP_005550 NP_032506 Location (UCSC) Chr 18: 6.94 – 7.12 Mb Chr 17: 68 – 68.13 Mb PubMed search [3] [4]
Wikidata
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Interactions

Laminin, alpha 1 has been shown to interact with FBLN2.^[7][8]

Role in pathology

Mutations of the LAMA1 gene cause the Poretti–Boltshauser syndrome.