List of polysubstance combinations

Not to be confused with Lacing (drugs) § Commonly laced substances.

Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.

A drug combination chart designed for harm reduction by TripSit^[1]

Table

To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.

Drug 1	Drug 2	Drug 3	Drug 4	Polysubstance slang,[2][3][4] or brand name	Intoxication name	Comment
Any dissociative	Any dissociative			Void flip	Void flipping
Any dissociative	DMT			Dime bar, angel flip	Dimension flipping, angel flipping
Any depressant	Any stimulant			Speedball, powerball, over and under	Powerballing, speedballing[5]
Any pharmaceutical	Any pharmaceutical			Polypharmacy	Pharming [citation needed]	Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[6]
Any drug	Cannabis			Amp joint[7]
Any β-Carboline containing plant (e.g. Banisteriopsis caapi or Peganum harmala)	DMT			Ayahuasca, Changa		Ayahuasca is drunk. Changa is smoked or vaped.
Any antiretroviral drug	Black tar heroin			Whoonga, Nyaope [8]		Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
Any Benzodiazepine	Psilocybin or psilocybin mushrooms		Warp Trip	Warping / Warp Tripping		When taken recreationally, a combination of benzodiazepine and psilocybin may soothe some of the more extreme negative effects often experienced during the peak and comedown phases of a psychedelic trip. Although benzodiazepines do not counteract the hallucinogenic and euphoric sensations caused by Psilocybin (commonly found in psilocybin mushrooms), they are sometimes administered by medical professionals to mitigate symptoms of a "bad trip." This practice helps to gradually relieve overactive sensory responses and induces relaxation in the individual, easing their mental state.[9]
Any deliriant or diphen­hydramine	MDMA			Nightmare flip	Nightmare flipping
2C-B or the closely related 2C-x	LSD or any of the Lysergamides	MDMA or any Empathogen-entactogen		Ali flip[10]	Ali flipping[10]	This combination start as a classic Candyflip and end in a Nexus flip. The LSD[11] is taken first, followed by the MDMA 4 hours later and then 2C-B[11] is taken 2 hours after the MDMA[11] ( so 6 hours after the LSD ). MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY. This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping"[12] with a twist in the end and a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other.
2C-B or the closely related 2C-x	Mescaline	MDMA or any Empathogen-entactogen		Selma flip[13][14][10]	Selma flipping[15][14][10]	This combination start as a classic Love flip and end in a Nexus flip. The Mescaline is taken first, followed by the MDMA 4 to 5 hours later and then 2C-B is taken 2 hours after the MDMA . MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the Mescaline, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY. This combination's goal is to have an experience close to an Ali Flip,[16] but more focused on the empathogenic effects, like the Elias Flip. The idea is to experience an enhanced "Love Flip" with a twist with the 2C-B with a smoother comedown. The whole experience is very long-lasting and can be too intense, as all of these molecules synergize and potentiate each other. Be careful, as some Mescaline cacti may contain MAOIs, which can interact dangerously with serotonergic empathogens.
2C-B	MDMA			Nexus flip[15][14]	Nexus flipping[15][14]	The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½). The 2C-B is supposed to help the empathogenic effect of the MDMA last longer.
2C-B	DXM			Nexuswalk[17]	Nexuswalk	Nexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
2C-B	LSD					There is no official name for this combination, when an empathogen like MDMA is added to this combination it becomes an Ali Flip.
2C-E	LSD	MDMA		Haychmaich flip[5]	Haychmaich flipping
2C-P	2C-E			Meskini Trip	Meskini Tripping
2C-E	MDMA or any Empathogen-entactogen	2C-B or the closely related 2C-x		Elias flip[15][14]	Elias flipping[15][14]	The Elias Flip inspired by the Ali Flip[10] with the use of 2C-E instead of LSD, it can have effects similar to a Selma Flip but with a shorter duration. Be careful with this combination, as 2C-E can have a heavy body load and is different from other 2C-x drugs.
2C-E	LSD or closely related Lysergamides	MDMA or any Empathogen	2C-B or closely related 2C-x	Alias Flip[10]	Alias flipping[10]	The Alias flip is a very powerful mix between an Elias flip and an Ali flip.[10] The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E.
2C-B-Fly	MDMA or any Empathogen-entactogen	2C-B or the closely related 2C-x		Ivan flip[15][14]	Ivan flipping[15][14]	The Ivan Flip inspired by the Ali Flip[10] with the use of 2C-B-Fly instead of LSD, it can have effects similar to a Selma Flip as 2C-B-Fly is closely related to Mescaline with a shorter duration. Be careful with this combination, as 2C-B-Fly can have a heavy body load and is different from other 2C-x drugs as it is part of the FLY (psychedelics) family.
Alcohol	Caffeine			Caffeinated alcoholic drink	Irish Coffee
Alcohol	Cannabis			Tincture of cannabis. Herb and Al. Judgement Day	Cross fading, twisting, getting twisted[18]	Called Judgement Day in Ghana when cannabis is added to the drink
Alcohol	Cocaine			Snow-cone	Snow-coning	Ethanol is metabolized into cocaethylene[19]
Alcohol	MDMA			Tipsy flip	Tipsy flipping	It may be dangerous
Alcohol	Nicotine			Nicotini		A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
Amphetamine	Barbiturates			Inbetweens[20] Bam
Amphetamine	Cannabis	LSD		Hippie heart attack [citation needed]
Amphetamine	Cocaine			Snow seals
Amphetamine	Heroin			Bombido[20]
Amphetamine	Xanax			Orange Dream Blossom	Cloud Rush	The combination is crushed together and insufflated
Belladonna	Hashish			Alamout black hash[5]		Mixed
Caffeine	Cannabis			Hippie-speedball[21][22]	Hippie-speedballing
Caffeine	Diphen­hydramine			Sleep walk	Sleepwalking
Caffeine	Meth­amphetamine			Ya ba, biker's coffee, kamikaze
Cacao bean	Magic mushroom					Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
CBD	THC					Low to moderate doses of CBD might reduce some of the paranoia, anxiety,[23] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.[24][25][26] Low doses of Kanna might also help counteract the anxiety.[27][28]
Cannabis	Cocoa solids			Cannabis-infused brownie		Cannabis edible
Cannabis	Crack cocaine			Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)[29]	Cocoa puffs, splitting
Cannabis	Crack cocaine	Heroin		Major Pronin, El Diablo
Cannabis	Crack cocaine	PCP		Jim Jones
Cannabis	Damiana					Damiana and other herbs can be used as a tobacco alternative for rolling joints.[30]
Cannabis	DXM	Nicotine		Candy blunt
Cannabis	Heroin or opium			A-bomb, Atom bomb, stuff[5]
Cannabis	MDMA			Stoner flip	Stoner flipping
Cannabis	Ketamine			Stoner Kitty
Cannabis	Ketamine	Cocaine		Simmered	Getting Simmered
Cannabis	Nicotine			Blunt, joint, spliff, Jonko		A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Cannabis	Opium			Demetra
Cannabis	PCP			Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom)	Illing	Wet is cannabis dipped in PCP [31]
Cannabis	PCP	Nicotine		Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt	Illing
Cocaine	Heroin			Snowball. Other names: Belushi, bombita, murder one, whiz bang	Snowballing
Cocaine	Heroin	LSD		Frisco special[5]
Cocaine	Heroin	Nicotine		Flamethrower, primos		Cigarette laced with cocaine and heroin
Cocaine	Ketamine			CK1, Calvin Klein, Cable, Party bag, Coquette
Cocaine	Ketamine	MDMA		Ketamollicaine
Cocaine	LSD	MDMA		Candy-flip on a string	Candy-flipping on a string	High risk on health
Cocaine	MDMA			Sugar flip	Sugar flipping
Cocaine	Morphine			C & M
Cocaine	PCP			Space, whack
Cocaine	Wine			Coca wine		Ethanol is metabolized into cocaethylene
Cocaine	Quetiapine			Q-ball
Codeine	Glutethimide			Pancakes and syrups		Combination of glutethimide and codeine cough syrup
Codeine	Promethazine			Lean, purple drank, oil
Crack cocaine	Fentanyl			Dirty fentanyl, takeover [citation needed]
Crack cocaine	Heroin			Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
Crack cocaine	LSD			Cracid, outerlimits
Crack cocaine	Meth­amphetamine			Fire, twisters
Crack cocaine	Nicotine			Coolie, crimmie, woolas
Crack cocaine	Nicotine	PCP		Ozone
Crack cocaine	PCP			Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic	Missile basing, space basing
Diphen­hydramine	DXM			OTC flip, counterflipping	OTC flipping, robowalking on a string
DMT	LSD			Cosmo flip, Meadow flip	Cosmo flipping, meadow flipping
DMT	LSD	Psilocybin or psilocybin mushroom		Super flip	Super flipping
DMT	MAOIs			Pharmahuasca
DMT	Psilocybin or psilocybin mushroom			Terence flip	Terence flipping
DMT	Nitrous oxide			Dimension flip	Dimension flipping	Nitrous oxide can, allegedly, briefly multiply the effects of psychedelics like DMT or NB-DMT[32]
DMT	Alcohol			Spyder, Spyder spin	Spyder spinning
DXM	LSD			LSDXM
DXM	MDMA			Robo flip	Robo flipping
DXM	Psilocybin or psilocybin mushroom			Cherry-bomb	Cherry-bombing
Fentanyl	Heroin			Birria, chiva loca, Facebook
Fentanyl (and/or heroin)	Xylazine			Tranq, Tranq dope
GHB	MDMA			Gamma flip	Gamma flipping
GHB	Meth­amphetamine			Cherry meth
Hashish	Crack cocaine			Double zero
Hashish	LSD			Royal temple ball
Hashish	Opium			Black hash, black Russian
Heroin	Meth­amphetamine			Goofball
Heroin	Morphine			New Jack swing
Heroin	PCP			Alien sex fiend[5]
Ketamine	Amphetamine			Fruit of the loom[33]
Ketamine	LSD			Dolphin flip	Dolphin flipping
Ketamine	MDMA			Kitty flip,[34] MK-ultra	Kitty flipping
Ketamine	Psilocybin or Psilocybin mushrooms			Funky flip, chonk	Funky flipping, chonking
LSD	Caffeine			Hoffmann Flip	Hoffmann flipping
LSD	Ketamine	MDMA		Holy Trident, Martin Luther King flip, Galaxy flip	Holy Tridenting, Martin Luther King flipping, Galaxy Flipping
LSD	MDMA			Candy flip[15][14]	Candy flipping[10][15][14]	Generally, the MDMA is taken approximately 4 hours after the LSD ingestion. A variant of this combination consist on adding 2C-B on top of it before the Candy Flip start coming down and it transforms it into a longer experience known as an Ali Flip.[10]
LSD	MDMA	Psilocybin or psilocybin mushroom		Jedi flip,[34] twilight flip	Jedi flipping, twilight flipping
LSD	MDMA	Mushrooms	Ketamine	Quantum Flip	Quantum Flipping
LSD	Nitrous oxide			Gasid		Nitrous oxide can, allegedly, briefly multiply the effects of psychedelics like LSD.[32]
LSD	PCP			Black acid
LSD	MDMA	Ketamine		Swalap Flip	Swalaped
LSD	Psilocybin or psilocybin mushroom			God's flesh, Soul Bomb, Alice,[5] Wizard flip	Wizard flipping
LSD	Dissociatives, especially long-lasting ones such as DMXE and/or DCK.	MDMA		Pixie flip	Pixie flipping
LSD	Dissociatives, especially long-lasting ones such as DMXE and/or DCK.	MDMA	DMT	Behind the curtain, portal flip	Climbing behind the curtain, portal flipping
LSD	Metocin (4-HO-MET)			Neon Bomb, Diamond Bomb	Neon Bombing, Diamond Bombing
MDMA	Mescaline or psychoactive cactus			Love flip, love trip	Love flipping	When 2C-B is added to this combination it becomes a Selma Flip.
MDMA	Methadone			Chocolate flip	Chocolate flipping
MDMA	Meth­amphetamine			Trailer flip	Trailer flipping
MDMA	DMT			Shaman flip, time flip	Shaman flipping, time flipping
MDMA	Nitrous oxide			Nox
MDMA	Opiates			Poppy flip	Poppy flipping
MDMA	PCP			Domex, elephant flip	Elephant flipping
MDMA	Psilocybin or psilocybin mushroom			Hippie flip	Hippie flipping[35]
MDMA or any Empathogen-entactogen	5-MeO-MiPT	2C-B or the closely related 2C-x		Stella Flipping[15][14]	Stella Flip[15][14]
MDMA	Viagra (or other PDE5 inhibitors such as Cialis or Levitra)			Sextacy
MDMA	Xanax			Zen flip	Zen flipping
MDMA	Ketamine	Mushrooms		Obama Flip	Obama Flipping
Meth­amphetamine	Secobarbital, or other barbiturates			Poor man's speedball
Methamphetamine	Alpha-PVP			Cartel meth
Methaqualone	Cannabis			White pipe[36][37]		Ingested by smoking. Popular in South Africa, elsewhere in Africa, and in India.[37]
Nicotine	PCP			Chipping, fry cigarette
Pentazocine	Tripelannamine			T's and blues
Venlafaxine	Mirtazepine			California rocket fuel

See also

• ACE mixture
• Brompton cocktail
• D-IX
• Desbutal
• Dexamyl
• Gray death
• Homebake (slang)
• Neuroleptanalgesic
• Rodent cocktail
• Tuinal
• Twilight sleep
• List of plants used for smoking