MAB21L2

Mab-21-like 2 (C. elegans) is a protein that in humans is encoded by the MAB21L2 gene.^[5]

MAB21L2
Identifiers
Aliases	MAB21L2, MCOPS14, Mab-21-like 2 (C. elegans), mab-21 like 2, MCSKS14
External IDs	OMIM: 604357; MGI: 1346022; HomoloGene: 7824; GeneCards: MAB21L2; OMA:MAB21L2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 150,582,151 bp[1] End 150,584,693 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 86,452,888 bp[2] End 86,455,936 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon pons retinal pigment epithelium dorsal motor nucleus of vagus nerve synovial joint superior vestibular nucleus transverse colon Achilles tendon cecum optic nerve Top expressed in maxillary prominence mandibular prominence abdominal wall superior cervical ganglion hand lens medial vestibular nucleus neural layer of retina iris embryonic cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus cytoplasm Biological process eye development multicellular organism development camera-type eye development nervous system development positive regulation of cell population proliferation embryonic body morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10586 23937 Ensembl ENSG00000181541 ENSMUSG00000057777 UniProt Q9Y586 Q8BPP1 RefSeq (mRNA) NM_006439 NM_011839 RefSeq (protein) NP_006430 NP_035969 Location (UCSC) Chr 4: 150.58 – 150.58 Mb Chr 3: 86.45 – 86.46 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008].