MAD2L2

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.^[5][6]

MAD2L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
Identifiers
Aliases	MAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV
External IDs	OMIM: 604094; MGI: 1919140; HomoloGene: 4624; GeneCards: MAD2L2; OMA:MAD2L2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,674,480 bp[1] End 11,691,650 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 148,130,384 bp[2] End 148,145,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left testis right testis granulocyte gastrocnemius muscle stromal cell of endometrium ventricular zone muscle of thigh right lobe of liver body of pancreas Top expressed in genital tubercle seminiferous tubule tail of embryo spermatocyte zygote ventricular zone morula secondary oocyte external carotid artery neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function JUN kinase binding protein binding Cellular component cytoplasm spindle nucleoplasm zeta DNA polymerase complex anaphase-promoting complex cytoskeleton nucleus nucleolus cytosol chromosome site of double-strand break Biological process DNA damage response, signal transduction resulting in transcription regulation of transcription, DNA-templated negative regulation of protein catabolic process actin filament organization negative regulation of cell-cell adhesion mediated by cadherin negative regulation of transcription by competitive promoter binding negative regulation of transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity transcription, DNA-templated mitotic spindle assembly checkpoint signaling positive regulation of peptidyl-serine phosphorylation error-prone translesion synthesis cellular response to DNA damage stimulus cell division positive regulation of transcription, DNA-templated negative regulation of transcription regulatory region DNA binding double-strand break repair regulation of cell growth cell cycle negative regulation of canonical Wnt signaling pathway negative regulation of epithelial to mesenchymal transition negative regulation of ubiquitin protein ligase activity DNA repair positive regulation of isotype switching negative regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair via nonhomologous end joining Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10459 71890 Ensembl ENSG00000116670 ENSMUSG00000029003 UniProt Q9UI95 Q9D752 RefSeq (mRNA) NM_001127325 NM_006341 NM_027985 NM_001305420 RefSeq (protein) NP_001120797 NP_006332 NP_001292349 NP_082261 Location (UCSC) Chr 1: 11.67 – 11.69 Mb Chr 4: 148.13 – 148.15 Mb PubMed search [3] [4]
Wikidata
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Function

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.^[6]

Interactions

MAD2L2 has been shown to interact with:

• ADAM9,^[7]
• MAD2L1,^[8]
• REV1,^[9] and
• REV3L.^[8][9]