ADAM9

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.^[5][6]

ADAM9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1V
Identifiers
Aliases	ADAM9, CORD9, MCMP, MDC9, Mltng, ADAM metallopeptidase domain 9
External IDs	OMIM: 602713; MGI: 105376; HomoloGene: 20824; GeneCards: ADAM9; OMA:ADAM9 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 38,996,754 bp[1] End 39,105,445 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 13.7 cM Start 25,439,627 bp[2] End 25,506,943 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium islet of Langerhans gallbladder smooth muscle tissue right lung Descending thoracic aorta Achilles tendon ascending aorta upper lobe of left lung rectum Top expressed in endothelial cell of lymphatic vessel stroma of bone marrow seminal vesicula retinal pigment epithelium epithelium of lens left lung lobe Paneth cell right lung parotid gland gastric mucosa More reference expression data BioGPS n/a
Gene ontology Molecular function collagen binding SH3 domain binding metal ion binding integrin binding peptidase activity protein binding metalloendopeptidase activity laminin binding hydrolase activity metallopeptidase activity protein kinase C binding Cellular component integral component of membrane membrane focal adhesion intrinsic component of external side of plasma membrane plasma membrane extracellular region extracellular exosome cell surface basolateral plasma membrane extracellular space Biological process positive regulation of membrane protein ectodomain proteolysis response to glucocorticoid positive regulation of macrophage fusion cell-cell adhesion mediated by integrin keratinocyte differentiation proteolysis monocyte activation response to calcium ion response to tumor necrosis factor positive regulation of keratinocyte migration cell adhesion response to manganese ion membrane protein ectodomain proteolysis positive regulation of protein secretion integrin-mediated signaling pathway positive regulation of cell adhesion mediated by integrin cell-matrix adhesion cellular response to lipopolysaccharide transforming growth factor beta receptor signaling pathway response to hydrogen peroxide cell migration cell adhesion mediated by integrin response to laminar fluid shear stress response to antineoplastic agent Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8754 11502 Ensembl ENSG00000168615 ENSG00000282230 ENSMUSG00000031555 UniProt Q13443 Q61072 RefSeq (mRNA) NM_001005845 NM_003816 NM_001270996 NM_007404 RefSeq (protein) NP_003807 NP_001257925 NP_031430 Location (UCSC) Chr 8: 39 – 39.11 Mb Chr 8: 25.44 – 25.51 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.^[6]

Interactions

ADAM9 has been shown to interact with:

• MAD2L2,^[7]
• SH3GL2,^[8] and
• SNX9^[8]